2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. 123B9

123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a Kd value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors.

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Custom Peptide Synthesis

123B9 Chemical Structure

123B9 Chemical Structure

CAS No. : 2225868-19-7

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Based on 1 publication(s) in Google Scholar

123B9 Related Antibodies

Top Publications Citing Use of Products

View All Ephrin Receptor Isoform Specific Products:

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EphA2 EphA3 EphA4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a Kd value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors[1].

IC50 & Target

Kd: 4.0 μM (EphA2)[1]
In Vivo

In mice, the mean plasma concentration over time following 123B9 IV administration (30 mg/kg) indicated that the compound is detectable in vivo at each time point tested (30 min, 1 hr, 2 hr, 4 hr) with a mean concentration in plasma of 447 ng/mL and 569 ng/mL still detectable at 2 hr and 4 hr, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1321.79

Formula

C58H82ClFN12O20
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{2-(3-chloro-4-fluorophenoxy)acetic acid}-Ser-Ala-Tyr-Pro-Asp-Ser-Val-Pro-{Nle}-{Hsr}-Ser-NH2
Sequence Shortening

{2-(3-chloro-4-fluorophenoxy)acetic acid}-SAYPDSVP-{Nle}-{Hsr}-S-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (75.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7565 mL 3.7827 mL 7.5655 mL
5 mM 0.1513 mL 0.7565 mL 1.5131 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7565 mL 3.7827 mL 7.5655 mL 18.9137 mL
5 mM 0.1513 mL 0.7565 mL 1.5131 mL 3.7827 mL
10 mM 0.0757 mL 0.3783 mL 0.7565 mL 1.8914 mL
15 mM 0.0504 mL 0.2522 mL 0.5044 mL 1.2609 mL
20 mM 0.0378 mL 0.1891 mL 0.3783 mL 0.9457 mL
25 mM 0.0303 mL 0.1513 mL 0.3026 mL 0.7565 mL
30 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6305 mL
40 mM 0.0189 mL 0.0946 mL 0.1891 mL 0.4728 mL
50 mM 0.0151 mL 0.0757 mL 0.1513 mL 0.3783 mL
60 mM 0.0126 mL 0.0630 mL 0.1261 mL 0.3152 mL
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123B9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

123B92225868-19-7Ephrin ReceptorEphA2 agonisttumor-homing agentInhibitorinhibitorinhibit

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