HNMT - histamine N-methyltransferase Gene

Homo sapiens

Also known as HMT; MRT51; HNMT-S1; HNMT-S2

Gene ID: 3176 | Gene type: protein coding

About HNMT

Cytogenetic location: 2q22.1 Genomic coordinates (GRCh38): 2:137,964,473-138,016,364 (from NCBI)

This gene has 8 transcripts (splice variants), 263 orthologues and is associated with 3 phenotypes. Ubiquitous expression in liver (RPKM 20.0), fat (RPKM 16.4) and 24 other tissues.

Summary

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first Enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

HNMT Products(3)

mRNA	Protein	Name
NM_001024074.3	NP_001019245.1	histamine N-methyltransferase isoform 2
NM_001024075.3	NP_001019246.1	histamine N-methyltransferase isoform 3
NM_006895.3	NP_008826.1	histamine N-methyltransferase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histamine N-methyltransferase activity	IDA IDA: Inferred from direct assay	26206890	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in histamine catabolic process	IDA IDA: Inferred from direct assay	26206890	GOA
involved in histamine metabolic process	IMP IMP: Inferred from mutant phenotype	23505051	GOA
involved in methylation	IDA IDA: Inferred from direct assay	26206890	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26206890	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	23505051	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNMT Protein Structure

Methyltransf_23

0
100
200
292 a.a.

Protein Preferred Names

Protein Names

histamine N-methyltransferase

Recombinant HNMT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75811	HNMT Protein, Human (His)	AAH20677.1 (M1-A292)	≥95%

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 51

MRT51	Mental Retardation, Autosomal Recessive 51
Autosomal Recessive Intellectual Developmental Disorder 51

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Akinetopsia

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Strabismic Amblyopia

Suppression Amblyopia	Amblyopia
Amblyopia, Suppression

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Alzheimer Disease 19

AD19	Alzheimer'S Disease 19
Alzheimer Disease 19, Late-Onset	Alzheimer Disease 19 Late Onset
Late-Onset Alzheimer Disease	Alzheimer Disease, Late Onset, Susceptibility To, Type 19
Alzheimer Disease, Late Onset

Autotopagnosia

Body-Image Agnosia

Allergic Rhinitis

Hay Fever	Allergic Rhinitis, Susceptibility To
ALRH	Atopic Rhinitis
Seasonal Allergic Rhinitis	Non-Seasonal Allergic Rhinitis
Perenial Allergic Rhinitis	Pollenosis
Rhinitis Allergic Seasonal	Rhinitis, Allergic, Perennial
Allergic Rhinitis, Cause Unspecified	Pollinosis
Pollen Allergy	Allergy Nos Due To Pollen
Summer Catarrh	Other Seasonal Allergic Rhinitis

Form Agnosia

Eosinophilia-Myalgia Syndrome

Eosinophilia Myalgia Syndrome	Ems
L-Tryptophan Induced Ems	Severe Muscle Pain And Abnormally High Eosinophils
Syndrome With Inflammatory And Autoimmune Components That Affect The Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, And Heart

Food Allergy

Food Hypersensitivity	Food Allergies
Allergy Food	Food Allergen-Induced Hypersensitivity

Essential Tremor

Benign Essential Tremor	Familial Tremor
Hereditary Essential Tremor	Essential Hereditary Tremor
Shaky Hand Syndrome	Benign Essential Tremor Syndrome
Tremor Hereditary Essential	Essential Tremor, Susceptibility To
Tremor, Hereditary Essential

Visual Agnosia

Primary Visual Agnosia

Anisometropia

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Epithelial-Stromal Tgfbi Dystrophy

Prosopagnosia

Visual Cortex Disease

Visual Cortex Dysfunction	Visual Cortex Disorder
Visual Cortical Disorder	Disease Of Visual Cortex

Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Visual Pathway Disease

Disorder Of Visual Pathways

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Amblyopia

Lazy Eye

Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2

Epilepsy, Idiopathic Generalized 9

Epilepsy, Idiopathic Generalized, Susceptibility To, 9	EIG9
Epilepsy, Juvenile Myoclonic 6	Idiopathic Generalized Epilepsy 9
Epilepsy, Juvenile Myoclonic, Susceptibility To, 6	Susceptibility To Idiopathic Generalized Epilepsy 9
Juvenile Myoclonic Epilepsy 6	EJM6
Susceptibility To Juvenile Myoclonic Epilepsy 6	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9

Cortical Blindness

Blindness, Cortical

Sotos Syndrome

Cerebral Gigantism	SOTOS
Chromosome 5q35 Deletion Syndrome	Sotos Syndrome 1, Formerly
Sotos1, Formerly	Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development
Sotos Sequence	Sotos' Syndrome
Sotos1	Sotos Syndrome 1

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Weaver Syndrome

Wss	Weaver-Smith Syndrome
WVS	Weaver-Like Syndrome
Weaver-Williams Syndrome	Camptodactyly-Overgrowth-Unusual Facies Syndrome
Camptodactyly - Overgrowth - Unusual Facies	Ezh2 Related Overgrowth
Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly	Weaver Smith Syndrome
Weaver Like Syndrome	Weaver Williams Syndrome
Camptodactyly-Overgrowth-Unusual Facies	Weaver Syndrome 1
Weaver Syndrome 2	Wvs1
Wvs2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103056	DDD85646		99.72%	Unkown
HY-153021	NMT-IN-1	Inhibitor	≥98.0%	Unkown
HY-RS06259	HNMT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HNMT	RGD	RGD:71049
Felis catus	HNMT	VGNC	VGNC:80230
Bos taurus	HNMT	VGNC	VGNC:29893
Canis familiaris	HNMT	VGNC	VGNC:54805
Mus musculus	HNMT	MGD	MGI:2153181
Others	HNMT	NCBI