Sctr - secretin receptor Gene

Mus musculus

Also known as 6530402O03Rik

Gene ID: 319229 | Gene type: protein coding

About Sctr

Chromosome 1: 119,934,624-119,991,266 forward strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 130 orthologues, 41 paralogues and is associated with 30 phenotypes. Biased expression in stomach adult (RPKM 11.4), adrenal adult (RPKM 3.1) and 3 other tissues.

Summary

Enables Secretin Receptor activity. Involved in several processes, including diet induced thermogenesis; positive regulation of cAMP-mediated signaling; and water homeostasis. Predicted to be located in cytoplasmic microtubule. Predicted to be active in plasma membrane. Orthologous to human SCTR (Secretin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Sctr Products(2)

mRNA	Protein	Name
NM_001311077.1	NP_001298006.1	secretin receptor isoform 2 precursor
NM_001012322.2	NP_001012322.2	secretin receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables secretin receptor activity	IDA IDA: Inferred from direct assay	30449620	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	30449620	MGI
involved in diet induced thermogenesis	IDA IDA: Inferred from direct assay	30449620	MGI
involved in intracellular water homeostasis	IMP IMP: Inferred from mutant phenotype	17283064	MGI
involved in positive regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	30449620	MGI
involved in positive regulation of lipid catabolic process	IMP IMP: Inferred from mutant phenotype	24273196	MGI
involved in regulation of appetite	IDA IDA: Inferred from direct assay	30449620	MGI
involved in regulation of appetite	IMP IMP: Inferred from mutant phenotype	20927047	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17008357	MGI
involved in renal water absorption	IMP IMP: Inferred from mutant phenotype	17283064	MGI
involved in response to nutrient levels	IDA IDA: Inferred from direct assay	30449620	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sctr Protein Structure

HRM

7tmB1_secretin

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

secretin receptor

SCT-R

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12568	SCTR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12569	Sctr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12570	Sctr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sctr	NCBI	NCBI:6344

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