2. Gene
  3. AGFG2 - ArfGAP with FG repeats 2 Gene

AGFG2 - ArfGAP with FG repeats 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HRBL; RABR

Gene ID: 3268 | Gene type: protein coding

About AGFG2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,539,203-100,568,220 (from NCBI)

This gene has 5 transcripts (splice variants), 167 orthologues and 28 paralogues. Broad expression in salivary gland (RPKM 40.8), skin (RPKM 8.2) and 21 other tissues.

Summary

This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]

AGFG2 Products(1)

mRNA Protein Name
NM_006076.5 NP_006067.3 arf-GAP domain and FG repeat-containing protein 2

AGFG2 Protein Structure

ArfGap

ArfGap: Putative GTPase activating protein for Arf (39 - 145)

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  • 481 a.a.
Protein Preferred Names Protein Names

arf-GAP domain and FG repeat-containing protein 2

HIV-1 Rev-binding protein-like protein

Related Diseases

Diseases Alias
Jaw Cancer

Jaw Neoplasms

Jaw Neoplasm

Neoplasm Of Jaw

Cancer Of Jaw
Yellow Nail Syndrome

Yns

Lymphedema And Yellow Nails

Lymphedema With Yellow Nails

Lymphedema-Yellow Nails

LYYN

Hereditary Lymphedema And Yellow Nails

Hereditary Lymphoedema And Yellow Nails
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00446 AGFG2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus AGFG2 VGNC VGNC:25726
Rattus norvegicus AGFG2 RGD RGD:1306590
Macaca mulatta AGFG2 VGNC VGNC:80329
Mus musculus AGFG2 MGD MGI:2443267
Canis familiaris AGFG2 VGNC VGNC:37701
Felis catus AGFG2 VGNC VGNC:67647