HTN3 - histatin 3 Gene

Homo sapiens

Also known as PB; HIS2; HTN2; HTN5

Gene ID: 3347 | Gene type: protein coding

About HTN3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,028,459-70,036,538 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 15 orthologues and 2 paralogues. Restricted expression toward salivary gland (RPKM 33773.0).

Summary

This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as Antimicrobial Peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit Antibacterial, Antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]

HTN3 Products(1)

mRNA	Protein	Name
NM_000200.3	NP_000191.1	histatin-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IMP IMP: Inferred from mutant phenotype	26775844	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23499434	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	32751915	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	3286634	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	28261570	GOA
involved in defense response to fungus	IDA IDA: Inferred from direct assay	11083804	GOA
involved in defense response to fungus	IMP IMP: Inferred from mutant phenotype	28763199	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	3286634	GOA
involved in killing of cells of another organism	IMP IMP: Inferred from mutant phenotype	28763199	GOA
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	26775844	GOA
involved in positive regulation of wound healing	IDA IDA: Inferred from direct assay	18650243	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	3286634	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	32225006	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

histatin-3

basic histidine-rich protein

Recombinant HTN3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70298	Histatin-3/HTN3 Protein, Human	P15516 (D20-N51)	≥95%

Related Diseases

Diseases

Alias

Oral Candidiasis

Thrush	Candidiasis Of Mouth
Oral Moniliasis	Thrush, Oral
Candidiasis, Oral	Oral Thrush
Candidiasis	Equine Thrush

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

Candida Glabrata

Torulopsis Glabrata

Renal Artery Atheroma

Atherosclerosis Of Renal Artery	Renal Atherosclerosis
Atherosclerotic Renal Disease	Ras - [Renal Artery Stenosis]
Renal Arterial Arteriosclerosis	Renal Arterial Arteriosclerotic Disease
Renal Arterial Stricture	Renal Artery Stricture
Renal Artery Stenosis Of Unknown Cause	Renal Artery Stenosis Due To Atherosclerosis
Renal Artery Stenosis	Renal Artery Arteriosclerotic Disease
Renal Artery Arteriosclerosis

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Acute Apical Periodontitis

Acute Apical Periodontitis Of Pulpal Origin	Acute Apical Periodontitis Nos
Aap - [Acute Apical Periodontitis]

Renal Artery Disease

Renal Vascular Disease	Vascular Disorder Of Kidney
Renal Vascular Disorder

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06457	HTN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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