DNAJB11 - DnaJ heat shock protein family (Hsp40) member B11 Gene

Homo sapiens

Also known as DJ9; EDJ; Dj-9; ERj3; PKD6; ABBP2; ERdj3; ERj3p; ABBP-2; UNQ537; PRO1080

Gene ID: 51726 | Gene type: protein coding

About DNAJB11

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,570,720-186,585,793 (from NCBI)

This gene has 8 transcripts (splice variants), 225 orthologues, 11 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 37.3), appendix (RPKM 33.9) and 25 other tissues.

Summary

This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 Amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]

DNAJB11 Products(2)

mRNA	Protein	Name
NM_001378451.1	NP_001365380.1	dnaJ homolog subfamily B member 11 isoform 2 precursor
NM_016306.6	NP_057390.1	dnaJ homolog subfamily B member 11 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables misfolded protein binding	IDA IDA: Inferred from direct assay	28597544	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18923428	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	20335166	GOA
involved in protein maturation	IMP IMP: Inferred from mutant phenotype	29706351	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	20335166	GOA
part of protein folding chaperone complex	IPI IPI: Inferred from physical interaction	28597544	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB11 Protein Structure

DnaJ

DnaJ_C

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily B member 11

APOBEC1-binding protein 2

DNAJB11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	DNAJB11	Q9UBS4	slrP	Salmonella typhimurium	Q8ZQQ2	Y2H	20335166
Cross	DNAJB11	Q9UBS4	slrP	Salmonella typhimurium	Q8ZQQ2	Anti Tag CoIP	20335166
Cross	DNAJB11	Q9UBS4	slrP	Salmonella typhimurium	Q8ZQQ2	Pull Down	20335166
Cross	DNAJB11	Q9UBS4	slrP	Salmonella typhimurium	Q8ZQQ2	Confocal	20335166
Intra	DNAJB11	Q9UBS4	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	33961781
Intra	DNAJB11	Q9UBS4	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	28514442
Intra	DNAJB11	Q9UBS4	HSPA5	Homo sapiens	P11021	Pull Down	20335166
Intra	DNAJB11	Q9UBS4	SIMC1	Homo sapiens	Q8NDZ2	Anti Tag CoIP	33961781
Intra	DNAJB11	Q9UBS4	SIMC1	Homo sapiens	Q8NDZ2	Anti Tag CoIP	28514442
Intra	DNAJB11	Q9UBS4	SIMC1	Homo sapiens	Q8NDZ2	Y2H	21900206
Intra	DNAJB11	Q9UBS4	HTN3	Homo sapiens	P15516	Y2H Array	32296183
Intra	DNAJB11	Q9UBS4	HTN3	Homo sapiens	P15516	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Polycystic Kidney Disease 6 With Or Without Polycystic Liver Disease

PKD6

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Congenital Anomalies Of Kidney And Urinary Tract 1

CAKUT1	Renal Hypodysplasia, Nonsyndromic, 1
Rhdns1	Congenital Anomalies Of The Kidney And Urinary Tract 1
Non-Syndromic Renal Hypodysplasia 1	Kidney And Urinary Tract, Anomalies, Congenital, Susceptibility To, Type 1

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Renal-Hepatic-Pancreatic Dysplasia

Ivemark'S Syndrome	Ivemark Ii Syndrome
Renohepaticopancreatic Dysplasia

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Renal Dysplasia, Cystic

CYSRD	Renal Dysplasia, Cystic, Susceptibility To
Diffuse Cystic Renal Dysplasia	Renal Dysplasia Diffuse Cystic
Cystic Renal Dysplasia	Susceptibility To Cystic Renal Dysplasia
Dysplasia, Renal, Cystic, Susceptibility To	Multicystic Dysplastic Kidney

End Stage Renal Disease

End Stage Renal Failure	End-Stage Kidney Disease
Kidney Failure, Chronic	Chronic Kidney Disease Stage 5

Short-Rib Thoracic Dysplasia 9 With Or Without Polydactyly

Conorenal Syndrome	Saldino-Mainzer Syndrome
SRTD9	Mainzer-Saldino Syndrome
Mzsds	Mainzer-Saldino Disease
Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia, And Skeletal Dysplasia	Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dysplasia
Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dy	Mainzer Saldino Syndrome
Conorenal Dysplasia	Mainzer-Saldino Chondrodysplasia
Saldino-Mainzer Dysplasia	Short-Rib Thoracic Dysplasia 9
Renal Dysplasia-Retinal Pigmentary Dystrophy-Cerebellar Ataxia-Skeletal Dysplasia Syndrome	Mss
Renal Dysplasia Retinal Pigmentary Dystrophy Cerebellar Ataxia And Skeletal Dysplasia

Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease	Arpkd
Polycystic Kidney Disease, Autosomal Recessive	Polycystic Kidney And Hepatic Disease 1
Pkhd1	PKD4
Polycystic Kidney Disease 4 With Or Without Hepatic Disease	Polycystic Kidney Disease, Infantile, Type I
Polycystic Kidney Disease, Infantile Type	Polycystic Kidney, Autosomal Recessive
Pkd3, Formerly	Polycystic Kidney Disease 4, With Or Without Hepatic Disease
Arpkd/Chf	Ar-Pkd
Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease	Infantile Polycystic Kidney Disease Type I
Pkd3	Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease
Polycystic Kidney Disease 3, Autosomal Dominant

Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2	PKD2
Polycystic Kidney Disease, Adult, Type Ii	Apkd2
Polycystic Kidney Disease, Type 2	Adpkd2
Adult Polycystic Kidney Disease Type 2	Autosomal Dominant Polycystic Kidney Disease 2
Pkd-2	Polycystic Kidney Disease Adult Type Ii
Polycystic Kidney Type 2 Autosomal Dominant Disease	Kidney Disease, Polycystic, Type 2

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03864	DNAJB11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DNAJB11	VGNC	VGNC:102690
Rattus norvegicus	DNAJB11	RGD	RGD:1307373
Canis familiaris	DNAJB11	VGNC	VGNC:53459
Mus musculus	DNAJB11	MGD	MGI:1915088

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