HTR4 - 5-hydroxytryptamine receptor 4 Gene

Homo sapiens

Also known as 5-HT4; 5-HT4R

Gene ID: 3360 | Gene type: protein coding

About HTR4

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:148,451,032-148,654,527 (from NCBI)

This gene has 13 transcripts (splice variants), 201 orthologues and 25 paralogues. Biased expression in small intestine (RPKM 2.1), duodenum (RPKM 1.1) and 5 other tissues.

Summary

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]

HTR4 Products(8)

mRNA	Protein	Name
NM_000870.7	NP_000861.1	5-hydroxytryptamine receptor 4 isoform b
NM_001040169.2	NP_001035259.1	5-hydroxytryptamine receptor 4 isoform a
NM_001040173.2	NP_001035263.1	5-hydroxytryptamine receptor 4 isoform i
NM_001040174.1
NM_001040172.2	NP_001035262.2	5-hydroxytryptamine receptor 4 isoform d
NR_104445.2
NM_001286410.1	NP_001273339.1	5-hydroxytryptamine receptor 4 isoform c
NM_199453.3	NP_955525.1	5-hydroxytryptamine receptor 4 isoform g

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	9603189	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28298427	GOA
enables serotonin receptor activity	IDA IDA: Inferred from direct assay	33481771	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9603189	GOA
involved in adenylate cyclase-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	35714614	GOA
involved in large intestinal transit	IDA IDA: Inferred from direct assay	33481771	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15925089	GOA
located in membrane	IDA IDA: Inferred from direct assay	16102731	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	10821780	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR4 Protein Structure

7tm_1

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 4

5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled

cardiac 5-HT4 receptor

Related Diseases

Diseases

Alias

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Headache

Headache Disorder

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Gastrointestinal System Disease

Gastrointestinal Disease	Gastrointestinal Diseases
Alimentary System Disease	Digestive System Disorder
Gastroenteropathy	Gastrointestinal Disorder
Git Disease	Digestive System Diseases
Gastrointestinal Disorders	Digestive System Disease
Digestive System Disorders

Colonic Pseudo-Obstruction

Primary Chronic Pseudo-Obstruction Of Colon

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Functional Gastric Disease

Pylorospasm

Constipation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14153A	Tegaserod maleate		99.93%	Unkown
HY-14153	Tegaserod		99.89%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06474	HTR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06475	Htr4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06476	Htr4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-14153S	Tegaserod-d11		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HTR4	VGNC	VGNC:41831
Bos taurus	HTR4	VGNC	VGNC:30000
Mus musculus	HTR4	MGD	MGI:109246
Felis catus	HTR4	VGNC	VGNC:67675
Macaca mulatta	HTR4	VGNC	VGNC:73544
Rattus norvegicus	HTR4	RGD	RGD:2850

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