APOA4 - apolipoprotein A4 Gene

Homo sapiens

Gene ID: 337 | Gene type: protein coding

About APOA4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:116,820,700-116,823,304 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 3 paralogues. Restricted expression toward small intestine (RPKM 1486.2).

Summary

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol Acyltransferase in vitro. [provided by RefSeq, Jul 2008]

APOA4 Products(1)

mRNA	Protein	Name
NM_000482.4	NP_000473.2	apolipoprotein A-IV precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables antioxidant activity	IDA IDA: Inferred from direct assay	16945374	GOA
enables cholesterol transfer activity	IDA IDA: Inferred from direct assay	1935934	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	16945374	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22579246	GOA
enables lipid binding	IMP IMP: Inferred from mutant phenotype	16159879	GOA
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	1935934	GOA
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IDA IDA: Inferred from direct assay	1935934	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24311788	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	1935934	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cholesterol efflux	IDA IDA: Inferred from direct assay	1935934	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	1935934	GOA
involved in cholesterol metabolic process	IDA IDA: Inferred from direct assay	1935934	GOA
involved in high-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	1935934	GOA
involved in hydrogen peroxide catabolic process	IDA IDA: Inferred from direct assay	16945374	GOA
involved in innate immune response in mucosa	IDA IDA: Inferred from direct assay	15254593	GOA
involved in leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	15254593	GOA
involved in lipid catabolic process	IDA IDA: Inferred from direct assay	3095477	GOA
involved in lipid homeostasis	IDA IDA: Inferred from direct assay	3095477	GOA
involved in lipid transport	IDA IDA: Inferred from direct assay	1935934	GOA
involved in negative regulation of plasma lipoprotein oxidation	IDA IDA: Inferred from direct assay	16945374	GOA
involved in phosphatidylcholine metabolic process	IDA IDA: Inferred from direct assay	1935934	GOA
involved in phospholipid efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in positive regulation of CoA-transferase activity	IDA IDA: Inferred from direct assay	1935934	GOA
involved in positive regulation of fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	2307668	GOA
involved in positive regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	2307668	GOA
involved in positive regulation of triglyceride catabolic process	IDA IDA: Inferred from direct assay	2307668	GOA
involved in protein-lipid complex assembly	IMP IMP: Inferred from mutant phenotype	16159879	GOA
involved in regulation of cholesterol transport	IDA IDA: Inferred from direct assay	11940599	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	16945374	GOA
involved in response to lipid hydroperoxide	IDA IDA: Inferred from direct assay	16945374	GOA
involved in reverse cholesterol transport	IDA IDA: Inferred from direct assay	3095477	GOA
involved in very-low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	2307668	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with cell surface	IDA IDA: Inferred from direct assay	1935934	GOA
part of chylomicron	IDA IDA: Inferred from direct assay	3095477	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	1935934	GOA
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	3095477	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	3095477	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOA4 Protein Structure

Apolipoprotein

0
100
200
300
396 a.a.

Protein Preferred Names

Protein Names

apolipoprotein A-IV

apo-AIV

Recombinant APOA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7528	ApoA-IV Protein, Human (HEK293, His)	P06727 (E21-S396)	≥95%

Related Diseases

Diseases

Alias

Familial Hyperlipidemia

Familial Hyperlipoproteinemia	Hyperlipidaemia
Hyperlipoproteinemias	Hyperlipidemia
Hyperlipemia	Hyperlipidemias

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Carotenemia

Hypercarotinemia

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis	German Type Amyloidosis
Familial Renal Amyloidosis	Amyloidosis Viii
Amyloidosis, 3 Or More Types	Familial Visceral Amyloidosis
Familial Amyloid Nephropathy	Hereditary Amyloid Nephropathy
Amyloidosis, Familial Renal	Amyloidosis, Systemic Nonneuropathic
Amyloidosis Familial Visceral	Amyloidosis 8
Amyloidosis, Ostertag Type	Hereditary Amyloidosis With Primary Renal Involvement
Hereditary Renal Amyloidosis	Renal Amyloidosis
Amyloidosis, Renal	Systemic Nonneuropathic Amyloidosis
Amyloidosis Familial Renal	Amyloidosis Systemic Nonneuropathic
Hereditary Amyloidosis With Primary Renal Involement	AMYL8
Systemic Non-Neuropathic Amyloidosis	Amyloid Nephropathy

Apolipoprotein A-Iv Associated Amyloidosis

Aapoaiv Amyloidosis	Renal Aapoaiv Amyloidosis
Apolipoprotein A-Iv Amyloidosis

Thrombophilia Due To Hrg Deficiency

Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency	Hereditary Thrombophilia Due To Congenital Hrg Deficiency
Thph11

Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia	Combined Hyperlipidemia, Familial
Mixed Hyperlipidaemia	FCHL3
Hyperlipidemia, Familial Combined	Familial Multiple Lipoprotein-Type Hyperlipidemia
Hyperbetalipoproteinemia With Prebetalipoproteinemia	Type Iib Hyperlipoproteinemia
Hyperlipidemia Familial Combined	Hyperlipoproteinemia Type Iib
Mixed Hyperlipemia	Hyperlipidaemia, Group C
Familial Hypercholesterolaemia With Hyperlipaemia	Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia
Hyperbetalipoproteinaemia With Prebetalipoproteinaemia	Hypercholesterolaemia With Endogenous Hyperglyceridaemia
Prebetalipoproteinemia Hyperbetalipoproteinaemia	Remnant Hyperlipoproteinemia

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Chylomicron Retention Disease

CMRD	Anderson Disease
Lipid Transport Defect Of Intestine	Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells
Andd	Anderson Syndrome
Crd	Andersons Disease
Malabsorption Syndrome

Hypoalphalipoproteinemia, Primary, 2

Apolipoprotein A-I Deficiency	Hypoalphalipoproteinemia, Primary, 2, Autosomal Recessive
Primary Hypoalphalipoproteinemia 2	High Density Lipoprotein Deficiency
Apoa-I Deficiency	Familial Apoa-I Deficiency
Familial Hypoalphalipoproteinemia	FHA2
Apolipoprotein A-I

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Diabetes Mellitus

Diabetes

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Glycogen Storage Disease

Glycogenosis	Glycogenoses
Gsd	Storage Disease, Glycogen
Gsd - [Glycogen Storage Disease]	Glycogen Thesaurismosis
Diffuse Glycogenosis	Generalised Glycogen Storage Disease
Generalised Glycogenosis	Generalised Glycogen Storage Disease Of Infants
Glycogen Synthase Deficiency

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00831	APOA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOA4	MGD	MGI:88051
Felis catus	APOA4	VGNC	VGNC:81902
Rattus norvegicus	APOA4	RGD	RGD:2132
Macaca mulatta	APOA4	VGNC	VGNC:82104
Bos taurus	APOA4	VGNC	VGNC:26024
Canis familiaris	APOA4	VGNC	VGNC:53263
Others	APOA4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.