1. Gene
  2. MAGEA6 - MAGE family member A6 Gene

MAGEA6 - MAGE family member A6 Gene

Homo sapiens

Also known as CT1.6; MAGE6; MAGE3B; MAGE-3b

Gene ID: 4105 | Gene type: protein coding

About MAGEA6

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:152,766,136-152,769,689 (from NCBI)

This gene has 4 transcripts (splice variants), 302 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 6.4).

Summary

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each Other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

MAGEA6 Products(2)

mRNA Protein Name
NM_005363.5 NP_005354.1 melanoma-associated antigen 6
NM_175868.4 NP_787064.1 melanoma-associated antigen 6
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20864041 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of autophagy IDA
IDA: Inferred from direct assay
31267705 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEA6 Protein Structure

MAGE_N

MAGE_N: Melanoma associated antigen family N terminal (4 - 97)

MAGE

MAGE: MAGE family (116 - 286)

  • 0
  • 100
  • 200
  • 314 a.a.
Protein Preferred Names Protein Names

melanoma-associated antigen 6

MAGE-6 antigen

MAGEA6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAGEA6 P43360 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
MAGEA6 P43360 IQUB Homo sapiens Q8NA54
Validated Y2H
25416956
Intra
MAGEA6 P43360 IQUB Homo sapiens Q8NA54
Y2H Array
25416956
Intra
MAGEA6 P43360 BFSP2 Homo sapiens Q13515
Validated Y2H
32296183
Intra
MAGEA6 P43360 CTF1 Homo sapiens Q16619
Validated Y2H
25416956
Intra
MAGEA6 P43360 CTF1 Homo sapiens Q16619
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 CTF1 Homo sapiens Q16619
Y2H Array
25416956
Intra
MAGEA6 P43360 SNAP47 Homo sapiens Q5SQN1
Validated Y2H
25416956
Intra
MAGEA6 P43360 SNAP47 Homo sapiens Q5SQN1
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 SNAP47 Homo sapiens Q5SQN1
Y2H Array
25416956
Intra
MAGEA6 P43360 FRMPD1 Homo sapiens Q5SYB0
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 FRMPD1 Homo sapiens Q5SYB0
Y2H Array
25416956
Intra
MAGEA6 P43360 CCDC146 Homo sapiens Q8IYE0-2
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 CCDC146 Homo sapiens Q8IYE0-2
Validated Y2H
25416956
Intra
MAGEA6 P43360 ELMOD3 Homo sapiens Q96FG2
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 ELMOD3 Homo sapiens Q96FG2
Validated Y2H
25416956
Intra
MAGEA6 P43360 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra
MAGEA6 P43360 CCDC24 Homo sapiens Q8N4L8
Validated Y2H
32296183
Intra
MAGEA6 P43360 ATPAF2 Homo sapiens Q8N5M1
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 ATPAF2 Homo sapiens Q8N5M1
Validated Y2H
32296183
Intra
MAGEA6 P43360 DLGAP4 Homo sapiens Q9Y2H0-1
Validated Y2H
32296183
Intra
MAGEA6 P43360 TSPYL6 Homo sapiens Q8N831
Validated Y2H
32296183
Intra
MAGEA6 P43360 BOLA3 Homo sapiens Q53S33
Validated Y2H
32296183
Intra
MAGEA6 P43360 LCORL Homo sapiens Q8N3X6-3
Validated Y2H
32296183
Intra
MAGEA6 P43360 CTF1 Homo sapiens Q16619-2
Validated Y2H
32296183
Intra
MAGEA6 P43360 NOSTRIN Homo sapiens Q8IVI9-3
Validated Y2H
32296183
Intra
MAGEA6 P43360 q9bs57_human Homo sapiens Q9BS57
Validated Y2H
32296183
Intra
MAGEA6 P43360 LIN52 Homo sapiens Q52LA3
Validated Y2H
32296183
Intra
MAGEA6 P43360 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra
MAGEA6 P43360 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra
MAGEA6 P43360 PDE4D Homo sapiens Q08499
Y2H Array
25416956
Intra
MAGEA6 P43360 PDE4D Homo sapiens Q08499
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 q6zrv7_human Homo sapiens Q6ZRV7
Validated Y2H
32296183
Intra
MAGEA6 P43360 TRIM26 Homo sapiens Q12899
Validated Y2H
32296183
Intra
MAGEA6 P43360 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 HAUS1 Homo sapiens Q96CS2
Y2H Array
25416956
Intra
MAGEA6 P43360 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
32296183
Intra
MAGEA6 P43360 MIPOL1 Homo sapiens Q8TD10
Y2H Array
25416956
Intra
MAGEA6 P43360 BCL7B Homo sapiens Q9BQE9
Validated Y2H
25416956
Intra
MAGEA6 P43360 BCL7B Homo sapiens Q9BQE9
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 BCL7B Homo sapiens Q9BQE9
Validated Y2H
32296183
Intra
MAGEA6 P43360 DCTN1 Homo sapiens Q14203-5
Y2H Array
32814053
Intra
MAGEA6 P43360 DCTN1 Homo sapiens Q14203-5
Y2H Pooling
32814053
Intra
MAGEA6 P43360 DCTN1 Homo sapiens Q14203-5
Validated Y2H
32814053
Intra
MAGEA6 P43360 DNTTIP1 Homo sapiens Q9H147
Validated Y2H
32296183
Intra
MAGEA6 P43360 ATOSA Homo sapiens Q32MH5
Validated Y2H
25416956
Intra
MAGEA6 P43360 ATOSA Homo sapiens Q32MH5
Y2H Array
25416956
Intra
MAGEA6 P43360 ACTN3 Homo sapiens Q08043
Validated Y2H
32296183
Intra
MAGEA6 P43360 RASSF4 Homo sapiens Q9H2L5
Validated Y2H
25416956
Intra
MAGEA6 P43360 RASSF4 Homo sapiens Q9H2L5
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 RASSF4 Homo sapiens Q9H2L5
Y2H Array
25416956
Intra
MAGEA6 P43360 RASSF4 Homo sapiens Q9H2L5
Validated Y2H
32296183
Intra
MAGEA6 P43360 LSM2 Homo sapiens Q9Y333
Y2H Array
25416956
Intra
MAGEA6 P43360 LSM2 Homo sapiens Q9Y333
Validated Y2H
32296183
Intra
MAGEA6 P43360 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
MAGEA6 P43360 RPL37A Homo sapiens P61513
Validated Y2H
25416956
Intra
MAGEA6 P43360 RPL37A Homo sapiens P61513
Validated Y2H
32296183
Intra
MAGEA6 P43360 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
MAGEA6 P43360 GADD45GIP1 Homo sapiens Q8TAE8
Validated Y2H
32296183
Intra
MAGEA6 P43360 HNRNPM Homo sapiens P52272
Validated Y2H
32296183
Intra
MAGEA6 P43360 TULP3 Homo sapiens O75386
Y2H Array
31515488
Intra
MAGEA6 P43360 TULP3 Homo sapiens O75386
Y2H Array
25416956
Intra
MAGEA6 P43360 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra
MAGEA6 P43360 PCBD2 Homo sapiens Q9H0N5
Validated Y2H
32296183
Intra
MAGEA6 P43360 KLHL38 Homo sapiens Q2WGJ6
Y2H Array
25416956
Intra
MAGEA6 P43360 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
25416956
Intra
MAGEA6 P43360 KLHL38 Homo sapiens Q2WGJ6
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
32296183
Intra
MAGEA6 P43360 TXNDC9 Homo sapiens O14530
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 TXNDC9 Homo sapiens O14530
Validated Y2H
25416956
Intra
MAGEA6 P43360 TXNDC9 Homo sapiens O14530
Y2H Array
25416956
Intra
MAGEA6 P43360 TXNDC9 Homo sapiens O14530
Y2H
21516116
Intra
MAGEA6 P43360 ATP6V1G1 Homo sapiens O75348
Y2H Array
25416956
Intra
MAGEA6 P43360 NCK2 Homo sapiens O43639
Validated Y2H
25416956
Intra
MAGEA6 P43360 NCK2 Homo sapiens O43639
Y2H Array
25416956
Intra
MAGEA6 P43360 LCORL Homo sapiens Q8N3X6
Validated Y2H
25416956
Intra
MAGEA6 P43360 STX5 Homo sapiens Q13190
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 STX5 Homo sapiens Q13190
Y2H Array
25416956
Intra
MAGEA6 P43360 XRCC4 Homo sapiens Q13426
Validated Y2H
32296183
Intra
MAGEA6 P43360 SNX4 Homo sapiens O95219
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 CCDC185 Homo sapiens Q8N715
Validated Y2H
32296183
Intra
MAGEA6 P43360 STAMBPL1 Homo sapiens Q96FJ0
Validated Y2H
25416956
Intra
MAGEA6 P43360 STAMBPL1 Homo sapiens Q96FJ0
Validated Y2H
32296183
Intra
MAGEA6 P43360 REX1BD Homo sapiens Q96EN9
Validated Y2H
32296183
Intra
MAGEA6 P43360 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra
MAGEA6 P43360 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra
MAGEA6 P43360 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra
MAGEA6 P43360 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
MAGEA6 P43360 LIN37 Homo sapiens Q96GY3
Y2H Array
25416956
Intra
MAGEA6 P43360 LIN37 Homo sapiens Q96GY3
Validated Y2H
25416956
Intra
MAGEA6 P43360 LIN37 Homo sapiens Q96GY3
Validated Y2H
32296183
Intra
MAGEA6 P43360 BET1 Homo sapiens O15155
Y2H Array
25416956
Intra
MAGEA6 P43360 TRIM28 Homo sapiens Q13263
TAP
20864041
Intra
MAGEA6 P43360 KIF27 Homo sapiens Q86VH2
Validated Y2H
32296183
Intra
MAGEA6 P43360 GFOD1 Homo sapiens Q9NXC2
Validated Y2H
25416956
Intra
MAGEA6 P43360 GFOD1 Homo sapiens Q9NXC2
Validated Y2H
32296183
Intra
MAGEA6 P43360 GFOD1 Homo sapiens Q9NXC2
Y2H Array
25416956
Intra
MAGEA6 P43360 GFOD1 Homo sapiens Q9NXC2
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 ACOT7 Homo sapiens O00154
Y2H Array
25416956
Intra
MAGEA6 P43360 EXOC5 Homo sapiens O00471
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 EXOC5 Homo sapiens O00471
Validated Y2H
25416956
Intra
MAGEA6 P43360 EXOC5 Homo sapiens O00471
Y2H Array
25416956
Intra
MAGEA6 P43360 AKAP9 Homo sapiens Q99996-2
Y2H Array
25416956
Intra
MAGEA6 P43360 AKAP9 Homo sapiens Q99996-2
Y2H Prey Pooling
25416956
Intra
MAGEA6 P43360 MORN3 Homo sapiens Q6PF18
Validated Y2H
25416956
Intra
MAGEA6 P43360 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Terminal Osseous Dysplasia

Terminal Osseous Dysplasia And Pigmentary Defects

Terminal Osseous Dysplasia-Pigmentary Defects Syndrome

Todpd

TOD

Odpd

Odpf Syndrome

Osseous Dysplasia, Digital, With Facial Pigmentary Defects And Multiple Frenula

Odpf

Digital Osseous Dysplasia With Facial Pigmentary Defects And Multiple Frenula

Terminal Osseous Dysplasia With Pigmentary Defects

Dcd

Digitocutaneous Dysplasia

Terminal Osseous Dysplasia And Pigmentary Defect Syndrome

Osseous Dysplasia And Pigmentary Defects

Transitional Papilloma

Transitional Cell Papilloma

Transitional Cell Papilloma, Benign

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome

Cold-Induced Sweating Syndrome

Crisponi Syndrome

Sohar-Crisponi Syndrome

Ciss

Cntf Receptor-Related Disorders

Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death

Sweating Syndrome, Cold-Induced

Distal Arthrogryposis

Arthrogryposis Multiplex Congenita

Arthrogryposis

Congenital Multiple Arthrogryposis

Congenital Arthromyodysplasia

Fibrous Ankylosis Of Multiple Joints

Guerin-Stern Syndrome

Guérin-Stern Syndrome

Myodystrophia Fetalis Deformans

Otto Syndrome

Rocher-Sheldon Syndrome

Rossi Syndrome

Amc

Multiple Congenital Arthrogryposis

Arthrogryposis Syndrome

Arthrogryposis, Distal

Distal Arthrogryposis Syndrome

Freeman-Sheldon Syndrome

Arthrogryposis, Distal, Type 2b

Congenital Multiplex Arthrogryposis

Amyoplasia Congenita

Congenital Amyoplasia

Amc - [Arthrogryposis Multiplex Congenita]

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma