NLRP9 - NLR family pyrin domain containing 9 Gene

Homo sapiens

Also known as NOD6; NALP9; PAN12; CLR19.1

Gene ID: 338321 | Gene type: protein coding

About NLRP9

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,708,438-55,738,402 (from NCBI)

This gene has 2 transcripts (splice variants), 77 orthologues and 20 paralogues. Biased expression in prostate (RPKM 1.0), testis (RPKM 0.4) and 9 other tissues.

Summary

The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, Caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

NLRP9 Products(1)

mRNA	Protein	Name
NM_176820.4	NP_789790.2	NACHT, LRR and PYD domains-containing protein 9

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28636595	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of canonical inflammasome complex	IDA IDA: Inferred from direct assay	28636595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLRP9 Protein Structure

PYRIN

NACHT

LRR_6

0
200
400
600
800
991 a.a.

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 9

NACHT, LRR and PYD containing protein 9

Related Diseases

Diseases

Alias

Night Blindness, Congenital Stationary, Type 1d

Congenital Stationary Night Blindness 1d	CSNB1D
Csnb, Complete, Autosomal Recessive	Night Blindness, Congenital Stationary , 1d, Autosomal Recessive
Congenital Stationary Night Blindness 1d Autosomal Recessive	Night Blindness, Congenital Stationary, 1d
Complete Autosomal Recessive Csnb	Blindness, Night, Stationary, Congenital, Type 1d

Petrositis

Acute Petrositis	Chronic Petrositis
Inflammation Of Petrous Bone	Osteitis Of Petrous Bone
Osteomyelitis Of Petrous Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09364	NLRP9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NLRP9	VGNC	VGNC:43852
Rattus norvegicus	NLRP9	RGD	RGD:1308981
Felis catus	NLRP9	VGNC	VGNC:63833
Bos taurus	NLRP9	VGNC	VGNC:32121
Others	NLRP9	NCBI

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