HCAR2 - hydroxycarboxylic acid receptor 2 Gene

Homo sapiens

Also known as HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A

Gene ID: 338442 | Gene type: protein coding

About HCAR2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,701,293-122,703,357 (from NCBI)

This gene has 1 transcript (splice variant), 168 orthologues and 15 paralogues.

Summary

Predicted to enable nicotinic acid receptor activity. Involved in neutrophil apoptotic process and positive regulation of neutrophil apoptotic process. Located in cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

HCAR2 Products(1)

mRNA	Protein	Name
NM_177551.4	NP_808219.1	hydroxycarboxylic acid receptor 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in neutrophil apoptotic process	IDA IDA: Inferred from direct assay	17932499	GOA
involved in positive regulation of neutrophil apoptotic process	IDA IDA: Inferred from direct assay	17932499	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	17932499	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCAR2 Protein Structure

7tm_1

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

hydroxycarboxylic acid receptor 2

G protein-coupled receptor HM74a	G-protein coupled receptor 109A
G-protein coupled receptor HM74A	hydroxy-carboxylic acid receptor 2
niacin receptor 1	nicotinic acid receptor

Related Diseases

Diseases

Alias

Pellagra

Niacin Deficiency	Niacin-Tryptophan Deficiency
Pellagroid Syndrome

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diversion Colitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156025	HCAR2 agonist 1		99.11%	Unkown
HY-RS06038	HCAR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06039	Hcar2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06040	Hcar2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HCAR2	RGD	RGD:727952
Mus musculus	HCAR2	MGD	MGI:1933383

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