TMEM119 - transmembrane protein 119 Gene

Homo sapiens

Also known as OBIF

Gene ID: 338773 | Gene type: protein coding

About TMEM119

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:108,589,851-108,598,084 (from NCBI)

This gene has 4 transcripts (splice variants) and 161 orthologues. Broad expression in gall bladder (RPKM 16.3), lymph node (RPKM 16.2) and 21 other tissues.

Summary

Involved in positive regulation of bone mineralization; positive regulation of osteoblast differentiation; and positive regulation of osteoblast proliferation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM119 Products(1)

mRNA	Protein	Name
NM_181724.3	NP_859075.2	transmembrane protein 119 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	20025746	GOA
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	20025746	GOA
involved in positive regulation of osteoblast proliferation	IDA IDA: Inferred from direct assay	20025746	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20025746	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transmembrane protein 119

osteoblast induction factor

Related Diseases

Diseases

Alias

Malignant Iris Melanoma

Malignant Melanoma Of Iris

Melanoma Of The Iris

Sciatic Neuropathy

Lesion Of Sciatic Nerve

Nerve Lesion Sciatic

Sciatic Neuropathy

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

Hereditary Diffuse Leukoencephalopathy With Spheroids	Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia
Alsp	Gpsc
Subcortical Gliosis Of Neumann	Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1
Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids	Hdls
HDLS1	Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia
Gliosis, Familial Progressive Subcortical	Leukoencephalopathy, Diffuse Hereditary, With Spheroids
Pold	Pigmentary Orthochromatic Leukodystrophy
Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia	Familial Progressive Subcortical Gliosis
Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant	Dementia, Familial, Neumann Type
Adult-Onset Leukodystrophy With Neuroaxonal Spheroids	Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids
Neuroaxonal Leukodystrophy	Fpsg
Familial Dementia, Neumann Type	Familial Dementia Neumann Type
Leukoencephalopathy, Diffuse Hereditary, With Spheroid

Mononeuritis Of Lower Limb

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14655	TMEM119 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.