JMJD8 - jumonji domain containing 8 Gene

Homo sapiens

Also known as PP14397; C16orf20

Gene ID: 339123 | Gene type: protein coding

About JMJD8

This gene has 15 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 36.7), kidney (RPKM 34.2) and 25 other tissues.

Summary

Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of sprouting angiogenesis; and regulation of glycolytic process. Located in endoplasmic reticulum lumen and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

JMJD8 Products(5)

mRNA	Protein	Name
NM_001005920.4	NP_001005920.3	jmjC domain-containing protein 8 isoform 1 precursor
NM_001323918.3	NP_001310847.2	jmjC domain-containing protein 8 isoform 2 precursor
NM_001323919.3	NP_001310848.2	jmjC domain-containing protein 8 isoform 3 precursor
NM_001323920.3	NP_001310849.2	jmjC domain-containing protein 8 isoform 4 precursor
NM_001323922.3	NP_001310851.2	jmjC domain-containing protein 8 isoform 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27199445	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	27671354	GOA
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	27199445	GOA
involved in regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	27199445	GOA
involved in regulation of pyruvate kinase activity	IMP IMP: Inferred from mutant phenotype	27199445	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27199445	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	29133832	GOA
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	29133832	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29133832	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JMJD8 Protein Structure

Cupin_8

0
100
200
285 a.a.

Protein Preferred Names

Protein Names

jmjC domain-containing protein 8

jumonji domain-containing protein 8

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 48

SCA48

Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16	SCAR16
Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency	Spinocerebellar Ataxia Autosomal Recessive Type 16
Spinocerebellar Ataxia, Autosomal Recessive, 16	Ataxia, Spinocerebellar, Autosomal Recessive, Type 16

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07041	JMJD8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	JMJD8	VGNC	VGNC:63008
Bos taurus	JMJD8	VGNC	VGNC:58602
Macaca mulatta	JMJD8	VGNC	VGNC:73826
Rattus norvegicus	JMJD8	RGD	RGD:1307381
Mus musculus	JMJD8	MGD	MGI:1919356
Canis familiaris	JMJD8	VGNC	VGNC:42190

Name
Email *

	Sorry, but the email address you supplied was invalid.