TMEM95 - transmembrane protein 95 Gene

Homo sapiens

Also known as UNQ9390

Gene ID: 339168 | Gene type: protein coding

About TMEM95

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,355,156-7,357,219 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele and 88 orthologues. Biased expression in testis (RPKM 4.1), thyroid (RPKM 3.1) and 1 other tissue.

Summary

Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in sperm plasma membrane. Predicted to be integral component of membrane. Predicted to be active in acrosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM95 Products(3)

mRNA	Protein	Name
NM_001320435.2	NP_001307364.1	sperm-egg fusion protein TMEM95 isoform 1 precursor
NM_001320436.2	NP_001307365.1	sperm-egg fusion protein TMEM95 isoform 3 precursor
NM_198154.3	NP_937797.1	sperm-egg fusion protein TMEM95 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM95 Protein Structure

TMEM95

0
100
176 a.a.

Protein Preferred Names

Protein Names

sperm-egg fusion protein TMEM95

TMEM95 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMEM95	Q3KNT9	CIB1	Homo sapiens	Q99828	Y2H Prey Pooling	32296183
Intra	TMEM95	Q3KNT9	CIB1	Homo sapiens	Q99828	Validated Y2H	32296183
Intra	TMEM95	Q3KNT9	CIB1	Homo sapiens	Q99828	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14749	TMEM95 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TMEM95	VGNC	VGNC:79671
Bos taurus	TMEM95	VGNC	VGNC:106985
Rattus norvegicus	TMEM95	RGD	RGD:1593310
Mus musculus	TMEM95	MGD	MGI:3779488
Felis catus	TMEM95	VGNC	VGNC:66373

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