ABCB5 - ATP binding cassette subfamily B member 5 Gene

Homo sapiens

Also known as ABCB5beta; EST422562; ABCB5alpha

Gene ID: 340273 | Gene type: protein coding

About ABCB5

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:20,615,667-20,757,008 (from NCBI)

This gene has 6 transcripts (splice variants), 136 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and Peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

ABCB5 Products(4)

mRNA	Protein	Name
NM_001163941.2	NP_001157413.1	ATP-binding cassette sub-family B member 5 isoform 1
NM_001163942.2	NP_001157414.1	ATP-binding cassette sub-family B member 5 isoform 3
NM_001163993.3	NP_001157465.1	ATP-binding cassette sub-family B member 5 isoform 4
NM_178559.6	NP_848654.3	ATP-binding cassette sub-family B member 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables efflux transmembrane transporter activity	IDA IDA: Inferred from direct assay	12960149	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	12960149	GOA
involved in transmembrane transport	IDA IDA: Inferred from direct assay	12960149	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12960149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCB5 Protein Structure

ABC_membrane

ABC_tran

ABC_membrane

ABC_tran

0
200
400
600
800
1000
1257 a.a.

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family B member 5

ABCB5 P-gp

Recombinant ABCB5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7621	ABCB5 Protein, Human (Trx)	Q2M3G0-4 (I586-V692)	≥95%

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Conjunctival Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Conjunctiva	Conjunctival Epidermoid Carcinoma
Invasive Squamous Cell Carcinoma Of The Conjunctiva	Ocular Surface Squamous Neoplasia

Cardiomyopathy, Dilated, 1o

Dilated Cardiomyopathy 1o	CMD1O
Dilated Cardiomyopathy With Ventricular Tachycardia	Cardiomyopathy, Dilated, With Ventricular Tachycardia
Cardiomyopathy, Dilated 1o	Cardiomyopathy, Dilated, Type 1o

Recessive Dystrophic Epidermolysis Bullosa

Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis	Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type
Rdeb, Hallopeau-Siemens Type	Severe Generalized Rdeb
Severe Generalized Recessive Dystrophic Epidermolysis Bullosa	Rdeb Generalisata Gravis
Rdeb, Severe Generalized	Rdeb-Sev Gen
Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized	Hallopeau-Siemens Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00052	ABCB5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ABCB5	VGNC	VGNC:49905
Felis catus	ABCB5	VGNC	VGNC:69335
Mus musculus	ABCB5	MGD	MGI:1924956
Macaca mulatta	ABCB5	VGNC	VGNC:80321
Bos taurus	ABCB5	VGNC	VGNC:25464
Rattus norvegicus	ABCB5	RGD	RGD:1566342
Others	ABCB5	NCBI

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