2. Gene
  3. LHFPL1 - LHFPL tetraspan subfamily member 1 Gene

LHFPL1 - LHFPL tetraspan subfamily member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 340596 | Gene type: protein coding

About LHFPL1

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:112,630,648-112,679,938 (from NCBI)

This gene has 2 transcripts (splice variants), 104 orthologues and 6 paralogues. Low expression observed in reference dataset.

Summary

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

LHFPL1 Products(1)

mRNA Protein Name
NM_178175.4 NP_835469.1 LHFPL tetraspan subfamily member 1 protein precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHFPL1 Protein Structure

L_HMGIC_fpl

L_HMGIC_fpl: Lipoma HMGIC fusion partner-like protein (8 - 192)

  • 0
  • 100
  • 200
  • 220 a.a.
Protein Preferred Names Protein Names

LHFPL tetraspan subfamily member 1 protein

LHFP-like protein 1

LHFPL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LHFPL1 Q86WI0 THSD7A Homo sapiens Q9UPZ6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07625 LHFPL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LHFPL1 RGD RGD:727927
Bos taurus LHFPL1 VGNC VGNC:30864
Mus musculus LHFPL1 MGD MGI:1891214
Macaca mulatta LHFPL1 VGNC VGNC:74260
Felis catus LHFPL1 VGNC VGNC:68042
Canis familiaris LHFPL1 VGNC VGNC:42657