2. Gene
  3. STAC2 - SH3 and cysteine rich domain 2 Gene

STAC2 - SH3 and cysteine rich domain 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 24b2; 24b2/STAC2

Gene ID: 342667 | Gene type: protein coding

About STAC2

This gene has 2 transcripts (splice variants), 238 orthologues and 2 paralogues. Biased expression in brain (RPKM 11.7), kidney (RPKM 2.2) and 3 other tissues.

Summary

This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate Calcium Channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017]

STAC2 Products(2)

mRNA Protein Name
NM_001351360.2 NP_001338289.1 SH3 and cysteine-rich domain-containing protein 2 isoform 2
NM_198993.5 NP_945344.1 SH3 and cysteine-rich domain-containing protein 2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAC2 Protein Structure

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (111 - 157)

SH3_9

SH3_9: Variant SH3 domain (299 - 347)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
Protein Preferred Names Protein Names

SH3 and cysteine-rich domain-containing protein 2

SRC homology 3 and cysteine-rich domain-containing protein 2

Related Diseases

Diseases Alias
Childhood-Onset Schizophrenia

Childhood Schizophrenia

Schizophrenia, Childhood
Myopathy, Congenital, Bailey-Bloch

Native American Myopathy

Nam

MYPBB

Myopathy, Congenital, Baily-Bloch

Anti-Hmg-Coa Myopathy

Anti-Srp Myopathy

Autoimmune Necrotizing Myositis

Imnm

Immune Myopathy With Myocyte Necrosis

Immune-Mediated Necrotizing Myopathy

Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia

Necrotizing Autoimmune Myopathy

Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome

Congenital Myopathy With Cleft Palate And Malignant Hyperthermia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13864 STAC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STAC2 MGD MGI:2144518
Felis catus STAC2 VGNC VGNC:65742
Canis familiaris STAC2 VGNC VGNC:46871
Bos taurus STAC2 VGNC VGNC:35351
Rattus norvegicus STAC2 RGD RGD:1305548
Macaca mulatta STAC2 VGNC VGNC:77979