TBX10 - T-box transcription factor 10 Gene

Homo sapiens

Also known as TBX7; TBX13

Gene ID: 347853 | Gene type: protein coding

About TBX10

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,631,303-67,641,754 (from NCBI)

This gene has 1 transcript (splice variant), 107 orthologues and 16 paralogues. Biased expression in colon (RPKM 3.2), small intestine (RPKM 3.1) and 1 other tissue.

Summary

This gene encodes a member of the T-box family of transcription factors. These transcription factors share a DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are thought to be a cause of isolated cleft lip with or without cleft palate. [provided by RefSeq, Nov 2010]

TBX10 Products(1)

mRNA	Protein	Name
NM_005995.5	NP_005986.2	T-box transcription factor TBX10

TBX10 Protein Structure

T-box

0
100
200
300
385 a.a.

Protein Preferred Names

Protein Names

T-box transcription factor TBX10

T-box 10

Related Diseases

Diseases

Alias

Cleft Lip With Or Without Cleft Palate

Tessier Cleft Number 1,2

Cleft Lip

Cheiloschisis	Labium Leporinum
Cleft Lip, Unilateral, Complete	Complete Unilateral Cleft Lip
Hare Lip	Congenital Fissure Of Lip
Isolated Cleft Lip	Cleft Lip Without Cleft Palate
Cleft Lip Without Cleft Palate, Unilateral	Isolated Cleft Lip, Unilateral
Cleft Lip Without Cleft Palate, Bilateral	Isolated Cleft Lip, Bilateral

Isolated Cleft Lip

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome	DGS
Hypoplasia Of Thymus And Parathyroids	Third And Fourth Pharyngeal Pouch Syndrome
22q11.2 Deletion Syndrome	Digeorge Sequence
Digeorge'S Syndrome	Pharyngeal Pouch Syndrome
Di-George Syndrome	Shprintzen Syndrome

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Ulnar-Mammary Syndrome

Schinzel Syndrome	UMS
Pallister Ulnar-Mammary Syndrome	Ulnar-Mammary Syndrome Of Pallister

Blepharocheilodontic Syndrome 1

Blepharocheilodontic Syndrome	Bcd Syndrome
Elschnig Syndrome	Clefting, Ectropion, And Conical Teeth
Lagophthalmia With Bilateral Cleft Lip And Palate	Blepharo-Cheilo-Odontic Syndrome
Bcds	Ectropion, Inferior, With Cleft Lip And/Or Palate
Blepharo-Cheilo-Dontic Syndrome	BCDS1
Ectropion Inferior Cleft Lip And Or Palate	Clefting-Ectropion-Conical Teeth Syndrome
Ectropion Inferior-Cleft Lip And/Or Palate Syndrome	Lagophthalmia-Cleft Lip And Palate Syndrome
Blepharocheilodontic Syndrome, Type 1

Van Der Woude Syndrome

Lip-Pit Syndrome	Vws
Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip	Vdws
Lps	Lip Pit Syndrome
Cleft Lip/Palate With Mucous Cysts Of Lower Lip	Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments

Orofacial Cleft

Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14271	TBX10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TBX10	VGNC	VGNC:66001
Rattus norvegicus	TBX10	RGD	RGD:1584144
Mus musculus	TBX10	MGD	MGI:1261436
Macaca mulatta	TBX10	VGNC	VGNC:107647
Canis familiaris	TBX10	VGNC	VGNC:49658
Bos taurus	TBX10	VGNC	VGNC:56286

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