ZACN - zinc activated ion channel Gene

Homo sapiens

Also known as L2; ZAC; ZAC1; LGICZ; LGICZ1

Gene ID: 353174 | Gene type: protein coding

About ZACN

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,079,182-76,082,806 (from NCBI)

This gene has 6 transcripts (splice variants), 111 orthologues and 45 paralogues. Ubiquitous expression in prostate (RPKM 23.1), brain (RPKM 20.2) and 25 other tissues.

Summary

LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]

ZACN Products(1)

mRNA	Protein	Name
NM_180990.4	NP_851321.2	zinc-activated ligand-gated ion channel precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ligand-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	26872532	GOA
enables ligand-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	12381728	GOA
enables pH-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	26872532	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	12381728	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	12381728	GOA
involved in response to zinc ion	IDA IDA: Inferred from direct assay	12381728	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	16083862	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZACN Protein Structure

Neur_chan_LBD

0
100
200
300
412 a.a.

Protein Preferred Names

Protein Names

zinc-activated ligand-gated ion channel

ligand-gated ion channel subunit

Related Diseases

Diseases

Alias

Amme Complex

Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis	ATS-MR
Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome	Chromosome Xq22.3 Telomeric Deletion Syndrome
Amme Syndrome	Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15949	ZACN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.