1. Gene
  2. KLK3 - kallikrein related peptidase 3 Gene

KLK3 - kallikrein related peptidase 3 Gene

Homo sapiens

Also known as APS; PSA; hK3; KLK2A1

Gene ID: 354 | Gene type: protein coding

About KLK3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,854,915-50,860,764 (from NCBI)

This gene has 15 transcripts (splice variants), 146 orthologues and 12 paralogues. Restricted expression toward prostate (RPKM 4286.7).

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. The gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a Protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]

KLK3 Products(3)

mRNA Protein Name
NM_001030047.1 NP_001025218.1 prostate-specific antigen isoform 3 preproprotein
NM_001030048.1 NP_001025219.1 prostate-specific antigen isoform 4 preproprotein
NM_001648.2 NP_001639.1 prostate-specific antigen isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
18714013 GOA
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IMP
IMP: Inferred from mutant phenotype
8665956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
1725227 GOA
enables serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
15563730 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of antibacterial peptide production IDA
IDA: Inferred from direct assay
18714013 GOA
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
15563730 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
8665956 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
8665956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK3 Protein Structure

Trypsin

Trypsin: Trypsin (25 - 253)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

prostate-specific antigen

P-30 antigen

Recombinant KLK3 Proteins

Cat. No. Product Name Accession Purity
HY-P70266 Kallikrein-3/PSA Protein, Human (244a.a, HEK293, His) P07288 (A18-P261) ≥95%
HY-P70606 Kallikrein-3/PSA Protein, Human (237a.a, HEK293, His) P07288 (I25-P261) ≥95%

Related Diseases

Diseases Alias
Prostatitis
Urethral Stricture

Ankylurethria

Urethral Stenosis

Urethral Contracture

Urethral Obstruction

Meatal Stenosis Nos

Constriction Of Urethra

Contraction Of Urethra

Stricture Of Urinary Meatus

Urethral Obliteration

Urethral Narrowing

Pinpoint Meatus

Pinhole Meatus Nos

Urethral Occlusion

Nodular Prostate
Urethral Syndrome

Urethral Disease

Urethral Diseases

Urethra Disease

Abnormality Of The Urethra

Urethral Disorders

Prostatic Adenoma

Prostatic Hyperplasia

Adenoma - Prostate

Adenoma Of Prostate

Benign Adenoma Of Prostate

Prostate Adenoma

Benign Prostatic Hyperplasia

Clear Cell Adenocarcinoma

Mesonephroma

Water-Clear Cell Adenocarcinoma

Adenocarcinoma, Clear Cell

Malignant Mesonephroma

Mesonephroid Clear Cell Carcinoma

Mesonephroma, Malignant

Water-Clear Cell Carcinoma

Wolffian Duct Neoplasm

Adenocarcinoma Clear Cell

Mesonephric Tumor

Gynecomastia
Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome

Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event

Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia

BPH

Prostatic Hyperplasia

Male Reproductive Organ Benign Neoplasm
Breast Cyst

Cyst Of The Breast

Breast Cysts

Prostate Disease

Prostatic Diseases

Prostate Diseases

Proctitis

Ulcerative Proctitis

Chronic Ulcerative Proctitis

Idiopathic Proctitis

Nonspecific Ulcerative Proctitis

Ulcerative Colitis Confined To Rectum

Ip - [Idiopathic Proctitis]

Chronic Ulcerative Proctitis Nos

Lymphocele

Lymph Cyst

Lymphocele Adverse Event

Lower Urinary Tract Calculus

Calculus Of Lower Urinary Tract

Bladder Calculus

Urinary Bladder Calculi

Urinary Bladder Stone

Bladder Calculi

Bladder Stone

Urinary Bladder Calculus

Vesical Calculi

Vesical Calculus

Vesicolithiasis

Cystolithiasis

Cystic Calculi

Cystic Calculus

Prostate Sarcoma

Sarcoma Of The Prostate

Seminal Vesicle Cystadenoma
Urinary Tract Obstruction

Obstructive Uropathy

Urinary Obstruction

Urologic Diseases

Prostate Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Prostate

Adenoid Cystic Carcinoma Of The Prostate

Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia

Prostate Calculus

Calculus Of Prostate

Prostatic Lithiasis

Stone Of Prostate

Prostatic Stone

Prostate Calculi

Prostatolithiasis

Prostate Leiomyoma

Prostatic Leiomyoma

Bladder Neck Obstruction

Obstruction Of Bladder Neck Or Vesicourethral Orifice

Urinary Bladder Neck Obstruction

Bladder Outlet Obstruction

Vesicourethral Orifice Obstruction

Bno - [Bladder Neck Obstruction]

Bladder Obstruction Nos

Acquired Bladder Neck Obstruction

Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice

Bladder Neck Strangulation

Bladder Neck Stricture

Bladder Outflow Obstruction

Contracture Of Bladder Neck Or Sphincter

Contracture Of Bladder Neck

Obstructed Vesicourethral Orifice

Strangulation Of Vesicourethral Orifice

Stricture Of Vesicourethral Orifice

Urinary Prostatic Valve Obstruction

Vesical Obstruction

Prostate Stromal Sarcoma

Stromal Sarcoma Of The Prostate

Urethral Calculus

Calculus In Urethra

Urethral Stone

Urethrolithiasis

Urethra Calculi Impaction

Urethra Calculus Impaction

Urethra Stone

Calculous Urethritis

Urethral Calculi Impaction

Urethral Calculus Impaction

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Prostate Signet Ring Cell Adenocarcinoma

Prostate Signet Ring Cell Carcinoma

Signet Ring Cell Carcinoma Of Prostate

Acinar Prostate Adenocarcinoma, Signet Ring Variant

Bladder Adenocarcinoma

Adenocarcinoma Of Bladder

Adenocarcinoma Of The Urinary Bladder

Bladder Adenocarcinoma, Not Otherwise Specified

Adenocarcinoma Bladder

Prostatic Acinar Adenocarcinoma

Acinar Prostate Adenocarcinoma

Small Intestinal Sarcoma

Sarcoma Of The Small Intestine

Prostatic Cyst

Cyst Of Prostate

Seminal Vesicle Tumor

Tumor Of Seminal Vesicle

Seminal Vesicle Neoplasm

Seminal Vesicle Tumour

Tumour Of Seminal Vesicle

Hypogonadism, Male

Male Hypogonadism

Hypogonadism Male

Testicular Hypogonadism

Pineal Dysgerminoma
Prostate Embryonal Rhabdomyosarcoma

Embryonal Rhabdomyosarcoma Of The Prostate

Endodermal Sinus Tumor

Yolk Sac Tumor

Endodermal Sinus Tumour

Hepatoid Yolk Sac Tumour

Infantile Embryonal Carcinoma

Yolk Sac Neoplasm

Yolk Sac Tumour

Breast Disease

Breast Diseases

Glossopharyngeal Nerve Paralysis
Lymph Node Carcinoma

Lymph Node Cancer

Lymph Node Neoplasm

Neoplasm Of Lymph Node

Seminal Vesicle Adenocarcinoma
Hypogonadism
Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos

Urinary System Disease

Abnormality Of The Urinary System

Non-Neoplastic Urinary Tract Disease

Urinary Tract Disease

Urinary Tract Diseases

Urinary Tract Anomaly

Urologic Diseases

Non-Neoplastic Urinary System Disorder

Congenital Malformation Of The Urinary System

Epididymis Disease
Transitional Cell Carcinoma

Transitional Cell Neoplasm

Carcinoma, Transitional Cell

Transitional Carcinoma

Transitional Cell Tumor

Urothelial Cell Carcinoma

Carcinoma Transitional Cell

Transitional Cell Carcinoma Of Bladder

Prostate Lymphoma

Lymphoma Of Prostate

Male Reproductive Organ Cancer

Genital Neoplasms, Male

Male Genital Cancer

Male Genital Neoplasm

Male Reproductive System Neoplasm

Malignant Neoplasm Of Male Genital Organ

Malignant Neoplasm Of Male Genital Organ Or Tract

Malignant Neoplasm Of Male Genital Organs

Malignant Tumor Of Male Genital Organ

Malignant Tumor Of Male Reproductive System

Neoplasm Of Male Genital Organ

Tumor Of Male Reproductive System

Adenosquamous Prostate Carcinoma

Adenosquamous Carcinoma Of Prostate

Adenosquamous Carcinoma Of The Prostate

Radiation Cystitis

Irradiation Cystitis

Prostatic Urethral Cancer
Nephrogenic Adenoma Of The Urethra

Nephrogenic Adenoma Of Urethra

Prostate Leiomyosarcoma

Leiomyosarcoma Of The Prostate

Female Breast Cancer

Female Breast Carcinoma

Carcinoma Of Female Breast

Mammary Carcinoma Of Female Breast

Malignant Neoplasm Of Female Breast

Male Reproductive System Disease

Genital Diseases, Male

Disorder Of Male Reproductive System

Prostate Small Cell Carcinoma

Small Cell Carcinoma Of Prostate

Prostate Oat Cell Carcinoma

Female Urethral Cancer

Female Urethral Malignant Neoplasm

Epididymo-Orchitis
Cystadenoma

Cystoma

Craniopharyngioma

Primary Cutaneous Amyloidosis

Plca

Primary Localized Cutaneous Amyloidosis

Familial Primary Localized Cutaneous Amyloidosis

Amyloidosis Ix

Lichen Amyloidosis Familial

Amyloidosis, Primary Cutaneous

Pca

Amyloidosis 9

Amyloidosis Familial Cutaneous Lichen

Fplca

Familial Lichen Amyloidosis

Sarcomatosis Of The Meninges

Meningeal Sarcomatosis

Sarcomatosis Of Meninges

Pyuria

Pus Cells In Urine

Bladder Diverticulum

Diverticulum Of Bladder

Diverticulum - Bladder

Bladder Diverticula

Vesical Diverticulum

Bladder Sacculation

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder

Neurogenic Urinary Bladder Disorder

Neuropathic Bladder

Bladder Neurogenic

Urinary Bladder, Neurogenic

Neurogenic Urinary Bladder

Urethra Cancer

Cancer Of Urethra

Malignant Tumour Of Urethra

Malignant Urethral Neoplasm

Urethral Ca

Rectal Disease

Rectal Diseases

Rectal Disorders

Castration-Resistant Prostate Carcinoma

Prostatic Neoplasms, Castration-Resistant

Nephrogenic Adenoma

Nephrogenic Metaplasia

Urethral Diverticulum

Urethral Sacculation

Urinary Tract Infection

Urinary Tract Infections

Uti

Urinary Tract Infection Nos

Uti - [Urinary Tract Infection]

Uti Nos - [Urinary Tract Infection Nos]

Urosepsis Nos

E Coli Uti

E Coli Urinary Tract Infection

Escherichia Coli Uti

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma

Adenocarcinoma Of Prostate

ST12

Prostate Adenocarcinoma 1

Pac1

Penile Urethral Cancer
Cystitis Cystica
Tuberculous Epididymitis

Tuberculosis Of Epididymis

Hemorrhoid

Hemorrhoids

Hemorrhoidal Disease

Rectal Diseases

Piles

Unspecified Haemorrhoids Without Complication

Urogenital Tuberculosis

Tuberculosis, Urogenital

Genitourinary Tuberculosis

Male Urethral Cancer

Male Urethral Malignant Neoplasm

Laryngeal Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Larynx

Urethritis

Nonspecific Urethritis

Non-Gonococcal Urethritis

Nongonococcal Urethritis

Ureterolithiasis

Calculus Of Ureter

Ureteric Stone

Ureteral Calculi

Ureteric Calculus

Stone In The Ureter

Ureter Calculi

Ureteral Calculus Or Stone

Ureterolith

Ureterolithiasis Nos

Prostate Rhabdomyosarcoma

Rhabdomyosarcoma Of The Prostate

Urethral Benign Neoplasm

Urethral Neoplasms

Neoplasm Of Urethra

Neoplasm. Urethra

Urethral Neoplasm

Urethral Carcinoma

Malignant Neoplasm Of Urethra

Cervical Adenoid Basal Carcinoma
Combined Oxidative Phosphorylation Deficiency 17

COXPD17

Combined Oxidative Phosphorylation Defect Type 17

Combined Oxidative Phosphorylation Deficiency, Type 17

Penile Disease

Penile Diseases

Small Cell Cancer Of The Lung

Small Cell Lung Cancer

Small Cell Lung Carcinoma

Sclc

Small-Cell Cancer Of Lung

Lung Small Cell Carcinoma

Sclc1

Sccl

Cancer, Lung, Small Cell

Small Cell Carcinoma Of Lung

Carcinoma, Small Cell

Female Stress Incontinence

Female Urinary Stress Incontinence

Stress Incontinence - Female

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Mixed Epithelial Stromal Tumour
Bone Disease

Bone Diseases

Skeletal Disease

Skeletal Disorder

Disorder Of Skeletal System

Prostate Neuroendocrine Neoplasm

Neuroendocrine Tumor Of The Prostate

Inguinal Hernia

Hernia Inguinal

Hernia, Inguinal

Inguinal Hernias

Bubonocele

Indirect Inguinal Hernia

Direct Inguinal Hernia

Oblique Inguinal Hernia

Scrotal Hernia

Ih - [Inguinal Hernia]

Reproductive System Disease

Abnormality Of The Genital System

Genital System Disease

Reproductive System Disorder

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Ureter Squamous Cell Carcinoma

Ureteral Epidermoid Carcinoma

Wolffian Duct Adenoma

Benign Mesonephroma

Mesonephric Adenoma

Mesonephroma, Benign

Fatwo

Female Adnexal Tumor Of Probable Wolffian Origin

Wat

Wolffian Adenoma

Wolffian Adnexal Tumor

Wolffian Tumor

Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders

Bladder Tuberculosis

Tuberculous Cystitis

Tuberculosis Of Bladder

Anus Disease

Anal Fissure

Ulcer Of Anus

Anus Diseases

Anal Disease

Anal Fissure And Fistula

Anal Ulcer

Fissure In Ano

Nontraumatic Tear Of Anus

Solitary Anal Ulcer

Abnormality Of The Anus

Anal Disorders

Ulcer Of Anus And Rectum

Solitary Ulcer Of Anus

Stercoral Ulcer Of Anus

Epididymis Adenocarcinoma

Adenocarcinoma Of The Epididymis

Epididymis Cancer

Malignant Tumor Of Epididymis

Malignant Epididymal Tumor

Malignant Neoplasm Of Epididymis

Neoplasm Of Epididymis

Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified

Intrahepatic Bile Duct Adenoma

Adenoma Of Intrahepatic Bile Duct

Adenoma Of The Intrahepatic Bile Duct

Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis

Diabetes Mellitus

Diabetes

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca fascicularis KLK3 NCBI
Mus musculus KLK3 NCBI
Rattus norvegicus KLK3 NCBI
Others KLK3 NCBI