2. Gene
  3. IL1RAP - interleukin 1 receptor accessory protein Gene

IL1RAP - interleukin 1 receptor accessory protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IL1R3; C3orf13; IL-1RAcP

Gene ID: 3556 | Gene type: protein coding

About IL1RAP

Cytogenetic location: 3q28 Genomic coordinates (GRCh38): 3:190,514,085-190,659,750 (from NCBI)

This gene has 19 transcripts (splice variants), 199 orthologues and 10 paralogues. Broad expression in liver (RPKM 11.2), placenta (RPKM 7.8) and 21 other tissues.

Summary

This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]

IL1RAP Products(9)

mRNA Protein Name
NM_001167928.2 NP_001161400.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_001167929.2 NP_001161401.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_001167930.2 NP_001161402.1 interleukin-1 receptor accessory protein isoform 2 precursor
NM_001167931.2 NP_001161403.1 interleukin-1 receptor accessory protein isoform 3 precursor
NM_001364879.1 NP_001351808.1 interleukin-1 receptor accessory protein isoform 3 precursor
NM_001364880.2 NP_001351809.1 interleukin-1 receptor accessory protein isoform 4 precursor
NM_001364881.2 NP_001351810.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_002182.4 NP_002173.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_134470.4 NP_608273.1 interleukin-1 receptor accessory protein isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
10854325 GOA
Biological Process GO Annotation Evidence Reference Source
involved in interleukin-1-mediated signaling pathway IDA
IDA: Inferred from direct assay
9065432 GOA
involved in interleukin-33-mediated signaling pathway IDA
IDA: Inferred from direct assay
17675517 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL1RAP Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (85 - 122)

Ig_2

Ig_2: Immunoglobulin domain (158 - 233)

TIR

TIR: TIR domain (408 - 544)

  • 0
  • 100
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  • 400
  • 500
  • 570 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor accessory protein

IL-1 receptor accessory protein

Recombinant IL1RAP Proteins

Cat. No. Product Name Accession Purity
HY-P72565 IL-1RAcP/IL-1 R3 Protein, Human (HEK293, His) Q9NPH3-1 (S21-E359) ≥95%
HY-P77413 IL-1RAcP/IL-1 R3 Protein, Human (HEK293, Fc) Q9NPH3-1 (S21-E359) ≥95%
HY-P78146 IL-1RAcP/IL-1 R3 Protein, Human (Biotinylated, HEK293, His-Avi) Q9NPH3-1 (S21-E359) ≥95%
HY-P78463 IL-1RAcP/IL-1 R3 Protein, Human (HEK293, His-Avi) Q9NPH3-1 (S21-E359) ≥95%

Related Diseases

Diseases Alias
Indolent Plasma Cell Myeloma

Indolent Myeloma

Indolent Multiple Myeloma
Chromosome Xp21 Deletion Syndrome

Complex Glycerol Kinase Deficiency

Xp21 Microdeletion Syndrome

Monosomy Xp21

Xp21 Deletion Syndrome

Complex Gkd

Del

Xp21 Contiguous Gene Deletion Syndrome

Glycerol Kinase Deficiency - Contiguous Gene Syndrome
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99379 Nidanilimab (Nadunolimab) Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06722 IL1RAP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IL1RAP RGD RGD:2893
Macaca mulatta IL1RAP VGNC VGNC:73718
Felis catus IL1RAP VGNC VGNC:97465
Mus musculus IL1RAP MGD MGI:104975
Canis familiaris IL1RAP VGNC VGNC:41960
Bos taurus IL1RAP VGNC VGNC:30133
Macaca fascicularis IL1RAP NCBI NCBI:102133222
Others IL1RAP NCBI