IL5RA - interleukin 5 receptor subunit alpha Gene

Homo sapiens

Also known as IL5R; CD125; CDw125; HSIL5R3

Gene ID: 3568 | Gene type: protein coding

About IL5RA

Cytogenetic location: 3p26.2 Genomic coordinates (GRCh38): 3:3,066,324-3,110,374 (from NCBI)

This gene has 11 transcripts (splice variants), 116 orthologues and 23 paralogues. Biased expression in lung (RPKM 1.2), prostate (RPKM 0.7) and 13 other tissues.

Summary

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

IL5RA Products(7)

mRNA	Protein	Name
NM_000564.5	NP_000555.2	interleukin-5 receptor subunit alpha isoform 1 precursor
NM_001243099.2	NP_001230028.1	interleukin-5 receptor subunit alpha isoform 4 precursor
NM_175724.2	NP_783851.1	interleukin-5 receptor subunit alpha isoform 2 precursor
NM_175725.3	NP_783852.1	interleukin-5 receptor subunit alpha isoform 3 precursor
NM_175726.4	NP_783853.1	interleukin-5 receptor subunit alpha isoform 1 precursor
NM_175727.2	NP_783854.1	interleukin-5 receptor subunit alpha isoform 2 precursor
NM_175728.3	NP_783855.1	interleukin-5 receptor subunit alpha isoform 3 precursor

IL5RA Protein Structure

IL6Ra-bind

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

interleukin-5 receptor subunit alpha

CD125 antigen

Recombinant IL5RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72539	IL-5R alpha Protein, Human (HEK293, His)	Q01344-1 (D21-E335)	≥95%
HY-P74800	IL-5R alpha Protein, Human (Q01344-2, HEK293, His)	Q01344-2 (D21-R335)	≥95%
HY-P78162	IL-5R alpha Protein, Human (Biotinylated, HEK293, His-Avi)	Q01344-1 (D21-E335)	≥95%
HY-P78471	IL-5R alpha Protein, Human (HEK293, His-Avi)	Q01344-1 (D21-E335)	≥95%

Related Diseases

Diseases

Alias

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Hypereosinophilic Syndrome

Eosinophilia	HES
Eosinophilic Leukocytosis	Hypereosinophilic Syndrome, Idiopathic
Idiopathic Hypereosinophilic Syndrome	Disseminated Eosinophilic Collagen Disease
Eosinophilic Disorder	Disorders With Increased Eosinophil Counts

Esophagitis

Acute Esophagitis

Disseminated Eosinophilic Collagen Disease

T2-Low Asthma

Type 2 Low Endotype

T2-High Asthma

Type 2 High Endotype

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Chronic Asthma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06773	IL5RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9923A	Benralizumab (anti-IL5RA )		99.60%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IL5RA	VGNC	VGNC:67780
Rattus norvegicus	IL5RA	RGD	RGD:70938
Canis familiaris	IL5RA	VGNC	VGNC:41991
Mus musculus	IL5RA	MGD	MGI:96558
Bos taurus	IL5RA	VGNC	VGNC:30165
Macaca mulatta	IL5RA	VGNC	VGNC:73731
Others	IL5RA	NCBI

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