1. Gene
  2. IL11RA - interleukin 11 receptor subunit alpha Gene

IL11RA - interleukin 11 receptor subunit alpha Gene

Homo sapiens

Also known as CRSDA

Gene ID: 3590 | Gene type: protein coding

About IL11RA

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,652,185-34,661,902 (from NCBI)

This gene has 27 transcripts (splice variants), 413 orthologues, 23 paralogues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 21.3), skin (RPKM 17.1) and 24 other tissues.

Summary

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 Receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

IL11RA Products(1)

mRNA Protein Name
NM_001142784.3 NP_001136256.1 interleukin-11 receptor subunit alpha precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables interleukin-11 receptor activity IDA
IDA: Inferred from direct assay
8637716 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in developmental process IMP
IMP: Inferred from mutant phenotype
21741611 GOA
involved in head development IMP
IMP: Inferred from mutant phenotype
21741611 GOA
involved in interleukin-11-mediated signaling pathway IDA
IDA: Inferred from direct assay
8637716 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-11 receptor subunit alpha

IL-11 receptor subunit alpha

IL11RA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IL11RA Q14626 OLFM4 Homo sapiens Q6UX06
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL11RA Proteins

Cat. No. Product Name Accession Purity
HY-P76416 IL-11R alpha Protein, Human (HEK293, His) Q14626-1/NP_004503.1 (S23-V363) ≥95%

Related Diseases

Diseases Alias
Craniosynostosis And Dental Anomalies

Kreiborg-Pakistani Syndrome

CRSDA

Craniosynostosis-Dental Anomalies

Craniosynostosis

Premature Closure Of Cranial Sutures

Craniostenosis

Craniosynostosis Syndrome

Cso

Craniosynostoses

Congenital Ossification Of Cranial Sutures

Congenital Ossification Of Sutures Of Skull

Craniostosis

Imperfect Fusion Of Skull

Congenital Imperfect Closure Skull

Imperfect Closure Skull

Premature Closure Cranium Sutures

Deficiency Of Craniofacial Axis

Hyper Ige Recurrent Infection Syndrome 4
Epilepsy, Familial Temporal Lobe, 2

Familial Temporal Lobe Epilepsy 2

Temporal Epilepsy, Familial

ETL2

Ftle

Epilepsy, Familial Temporal Lobe

Familial Temporal Lobe Epilepsy

Intellectual Developmental Disorder, Autosomal Dominant 22

MRD22

Mental Retardation, Autosomal Dominant 22

Autosomal Dominant Non-Syndromic Intellectual Disability 22

Distal Monosomy 1q

Autosomal Dominant Intellectual Developmental Disorder 22

Autosomal Dominant Mental Retardation 22

Distal Deletion 1q

Monosomy 1qter

Telomeric Deletion 1q

Mental Retardation, Autosomal Dominant, Type 22

Microphthalmia, Syndromic 3

MCOPS3

Aeg Syndrome

Microphthalmia And Esophageal Atresia Syndrome

Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome

Anophthalmia-Esophageal-Genital Syndrome

Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System

Syndromic Microphthalmia 3

Sox2 Anophthalmia Syndrome

Anophthalmia Clinical With Associated Anomalies

Anophthalmia Esophageal Genital Syndrome

Anophthalmia Microphthalmia Esophageal Atresia

Syndromic Microphthalmia Type 3

Sox2-Related Eye Disorders

Anophthalmia, Clinical, With Associated Anomalies

Syndromic Microphthalmia, Type 3

Microphthalmia, Syndromic, 3

Anophthalmia/Microphthalmia-Esophageal Atresia

Microphthalmia Syndromic, Type 3

Crouzon Syndrome

Crouzon Craniofacial Dysostosis

Craniofacial Dysostosis

Cfd1

Craniofacial Dysostosis Type 1

Crouzon Disease

Crouzon'S Disease

Craniofacial Dysostosis, Type I

Craniofacial Dysarthrosis

Craniofacial Dysostosis Syndrome

CS

Craniofacial Dysostosis Type I

Vogt Cephalosyndactyly

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IL11RA RGD RGD:621332
Felis catus IL11RA VGNC VGNC:102939
Bos taurus IL11RA VGNC VGNC:30109
Canis familiaris IL11RA VGNC VGNC:41931
Mus musculus IL11RA NCBI
Others IL11RA NCBI