IRF2BP2 - interferon regulatory factor 2 binding protein 2 Gene

Homo sapiens

Also known as CVID14

Gene ID: 359948 | Gene type: protein coding

About IRF2BP2

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:234,604,269-234,610,178 (from NCBI)

This gene has 3 transcripts (splice variants), 260 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 91.3), thyroid (RPKM 43.5) and 25 other tissues.

Summary

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

IRF2BP2 Products(2)

mRNA	Protein	Name
NM_001077397.1	NP_001070865.1	interferon regulatory factor 2-binding protein 2 isoform B
NM_182972.3	NP_892017.2	interferon regulatory factor 2-binding protein 2 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12799427	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in immature B cell differentiation	IDA IDA: Inferred from direct assay	27016798	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12799427	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12799427	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF2BP2 Protein Structure

IRF-2BP1_2

0
100
200
300
400
500
587 a.a.

Protein Preferred Names

Protein Names

interferon regulatory factor 2-binding protein 2

IRF-2-binding protein 2

Related Diseases

Diseases

Alias

Immunodeficiency, Common Variable, 14

CVID14

Common Variable Immunodeficiency 14

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Mesenchymal Chondrosarcoma

Chondrosarcoma, Mesenchymal

Chondrosarcoma Mesenchymal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06905	IRF2BP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRF2BP2	MGD	MGI:2443921
Rattus norvegicus	IRF2BP2	RGD	RGD:1589517
Bos taurus	IRF2BP2	VGNC	VGNC:30272
Canis familiaris	IRF2BP2	VGNC	VGNC:51901
Macaca mulatta	IRF2BP2	VGNC	VGNC:106391

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