Idh2 - isocitrate dehydrogenase (NADP(+)) 2 Gene

Rattus norvegicus

Gene ID: 361596 | Gene type: protein coding

About Idh2

Primary_assembly 1: 134,029,772-134,058,025 reverse strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 261 orthologues, 1 paralogue and is associated with 51 phenotypes. Biased expression in Heart (RPKM 8594.), Muscle (RPKM 35.7) and 4 other tissues.

Summary

Enables isocitrate dehydrogenase (NADP+) activity. Involved in several processes, including NADP biosynthetic process; negative regulation of glial cell proliferation; and negative regulation of matrix metallopeptidase secretion. Predicted to be located in cytosol and peroxisome. Predicted to be active in mitochondrion. Used to study status epilepticus. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung Cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Apr 2022]

Idh2 Products(1)

mRNA	Protein	Name
NM_001014161.1	NP_001014183.1	isocitrate dehydrogenase [NADP], mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables isocitrate dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	9354646	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in NADP biosynthetic process	IMP IMP: Inferred from mutant phenotype	21641335	RGD
involved in negative regulation of glial cell migration	IMP IMP: Inferred from mutant phenotype	22105553	RGD
involved in negative regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	21641335	RGD
involved in negative regulation of matrix metallopeptidase secretion	IMP IMP: Inferred from mutant phenotype	22105553	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Idh2 Protein Structure

PTZ00435

0
100
200
300
400
452 a.a.

Protein Preferred Names

Protein Names

isocitrate dehydrogenase [NADP], mitochondrial

ICD-M	IDH
IDP	NADP(+)-specific ICDH
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial	isocitrate dehydrogenase 2 (NADP+), mitochondrial
oxalosuccinate decarboxylase

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104042	Vorasidenib	Inhibitor	99.87%	Yes
HY-18690	Enasidenib	Inhibitor	99.90%	Yes
HY-18690A	Enasidenib mesylate	Inhibitor	99.85%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-131312	Crelosidenib	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15734	AGI-6780	Inhibitor	98.87%	Unkown
HY-149359	IHMT-IDH1-053	Inhibitor	/	Unkown
HY-164542	TQ05310	Inhibitor	/	Unkown
HY-120765	BRD2879	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Idh2	NCBI	NCBI:3418

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