2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. BRD2879

BRD2879 is a potent IDH1-R132H inhibitor with IC50 values of 0.05, 2.5, >20, >20 µM for IDH1-R132H, IDH1-R132C, IDH1-WT, IDH2-R140Q, respectively. BRD2879 reduces (R)-2-hydroxyglutarate (R-2HG) levels.

For research use only. We do not sell to patients.

BRD2879 Chemical Structure

BRD2879 Chemical Structure

CAS No. : 1304750-47-7

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BRD2879 Related Antibodies

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Description

BRD2879 is a potent IDH1-R132H inhibitor with IC50 values of 0.05, 2.5, >20, >20 µM for IDH1-R132H, IDH1-R132C, IDH1-WT, IDH2-R140Q, respectively. BRD2879 reduces (R)-2-hydroxyglutarate (R-2HG) levels[1].

IC50 & Target[1]

R132H IDH1

0.05 μM (IC50)

R132C IDH1

2.5 μM (IC50)

IDH1 wt

>20 μM (IC50)

IDH2-R140Q

>20 μM (IC50)

Molecular Weight

571.70

Formula

C30H38FN3O5S
CAS No.
SMILES

O=S1(C2=CC=C(C#CC3=CC(F)=CC=C3)C=C2O[C@H]([C@@H](CN1[C@@H](C)CO)C)CN(C)C(NC4CCCCC4)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRD2879 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD28791304750-47-7BRD 2879BRD-2879Isocitrate Dehydrogenase (IDH)HA1E-M cellsR-2HGATP levelU937cellsInhibitorinhibitorinhibit

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