BRD2879

Cat. No.: HY-120765: FAQs
Data Sheet Handling Instructions

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BRD2879 is a potent IDH1-R132H inhibitor with IC₅₀ values of 0.05, 2.5, >20, >20 µM for IDH1-R132H, IDH1-R132C, IDH1-WT, IDH2-R140Q, respectively. BRD2879 reduces (R)-2-hydroxyglutarate (R-2HG) levels.

For research use only. We do not sell to patients.

BRD2879 Chemical Structure

CAS No. : 1304750-47-7

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IDH1 IDH2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

R132H IDH1

0.05 μM (IC₅₀)

R132C IDH1

2.5 μM (IC₅₀)

IDH1 wt

>20 μM (IC₅₀)

IDH2-R140Q

>20 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	> 20 μM Compound: BRD2879	Inhibition of human C-terminal FLAG-tagged IDH1-R140Q mutant (1 to 452 residues) expressed in baculovirus infeceted sf9 cells assessed as inhibition of ketoreductase activity preincubated for 10 mins followed by addition of NADPH and alpha-KG as substrate Inhibition of human C-terminal FLAG-tagged IDH1-R140Q mutant (1 to 452 residues) expressed in baculovirus infeceted sf9 cells assessed as inhibition of ketoreductase activity preincubated for 10 mins followed by addition of NADPH and alpha-KG as substrate	[PMID: 27774134]

Molecular Weight

571.70

Formula

C₃₀H₃₈FN₃O₅S

CAS No.

1304750-47-7

SMILES

O=S1(C2=CC=C(C#CC3=CC(F)=CC=C3)C=C2O[C@H]([C@@H](CN1[C@@H](C)CO)C)CN(C)C(NC4CCCCC4)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Law JM, et al. Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1. ACS Med Chem Lett. 2016 Aug 18;7(10):944-949. [Content Brief]

BRD2879 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD28791304750-47-7BRD 2879BRD-2879Isocitrate Dehydrogenase (IDH)HA1E-M cellsR-2HGATP levelU937cellsInhibitorinhibitorinhibit

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