IMPG1 - interphotoreceptor matrix proteoglycan 1 Gene

Homo sapiens

Also known as RP91; VMD4; GP147; SPACR; IPM150

Gene ID: 3617 | Gene type: protein coding

About IMPG1

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:75,921,114-76,072,662 (from NCBI)

This gene has 4 transcripts (splice variants), 263 orthologues, 1 paralogue and is associated with 6 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

IMPG1 Products(2)

mRNA	Protein	Name
NM_001282368.2	NP_001269297.1	interphotoreceptor matrix proteoglycan 1 isoform 2 precursor
NM_001563.4	NP_001554.2	interphotoreceptor matrix proteoglycan 1 isoform 1 precursor

IMPG1 Protein Structure

SEA

0
200
400
600
797 a.a.

Protein Preferred Names

Protein Names

interphotoreceptor matrix proteoglycan 1

interphotoreceptor matrix proteoglycan of 150 kDa

Related Diseases

Diseases

Alias

Macular Dystrophy, Vitelliform, 4

VMD4	Vitelliform Macular Dystrophy 4

Retinitis Pigmentosa 91

Benign Concentric Annular Macular Dystrophy	RP91
Macular Dystrophy, Concentric Annular, Formerly	Mcdca, Formerly
Macular Dystrophy, Benign Concentric Annular, Formerly	Bcamd, Formerly
Bcamd	Macular Dystrophy, Benign Concentric Annular
Macular Dystrophy, Concentric Annular	Mcdca
Retinitis Pigmentosa, Type 91

Vitelliform Macular Dystrophy

Best Disease	Juvenile-Onset Vitelliform Macular Dystrophy
Macular Dystrophy, Vitelliform	Best Macular Dystrophy
Vitelliform Dystrophy

Macular Dystrophy, Vitelliform, 3

Adult-Onset Vitelliform Macular Dystrophy	Avmd
Adult-Onset Foveomacular Vitelliform Dystrophy	Aofmd
VMD3	Vitelliform Macular Dystrophy, Adult-Onset
Foveomacular Dystrophy, Adult-Onset, With Or Without Choroidal Neovascularization	Foveomacular Dystrophy, Adult-Onset, With Choroidal Neovascularization
Adult-Onset Foveomacular Dystrophy	Vitelliform Macular Dystrophy 3
Foveomacular Dystrophy, Adult-Onset	Foveomacular Dystrophy, Adult-Onset
Aofmd	Macular Dystrophy, Vitelliform, Adult-Onset
Adult-Onset Foveomacular Dystrophy With Choroidal Neovascularization	Gass Disease
Pseudo-Best Disease	Pseudo-Vitelliform Macular Dystrophy
Gas

Macular Dystrophy, Vitelliform, 2

Best Macular Dystrophy	Juvenile-Onset Vitelliform Macular Dystrophy
VMD2	Bmd
Macular Degeneration, Polymorphic Vitelline	Best Vitelliform Macular Dystrophy
Best Disease	Early-Onset Vitelliform Macular Dystrophy
Best Vitelliform Macular Dystrophy, Multifocal	Bvmd
Polymorphic Vitelline Macular Degeneration	Vitelliform Macular Dystrophy Type 2
Vitelliform Macular Dystrophy 2	Vitelliform Macular Dystrophy, Early-Onset
Vitelliform Macular Dystrophy, Juvenile-Onset	Autosomal Recessive Bestrophinopathy
Retinopathy, Burgess-Black Type	Best'S Macular Dystrophy
Vmd	Vitelliform Macular Dystrophy

Isolated Macular Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Macular Dystrophy, Concentric Annular

Mcdca

Maculopathy, Bull'S Eye

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Kahrizi Syndrome

KHRZ	Mental Retardation, Cataract, Coloboma, And Kyphosis, Autosomal Recessive
Intellectual Disability, Kahrizi Type	Intellectual Disability-Cataract-Coloboma-Kyphosis Syndrome

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Cone-Rod Dystrophy 3

CORD3

Dystrophy, Cone Rod, Type 3

Bestrophinopathy, Autosomal Recessive

Bestrophinopathy	Autosomal Recessive Bestrophinopathy
ARB	Bestrophinopathies
Retinopathy, Burgess-Black Type	Retinopathy Burgess-Black Type

Nasal Cavity Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Nasal Cavity

Squamous Cell Carcinoma Of The Nasal Cavity

Cone-Rod Dystrophy 7

CORD7	Dystrophy, Cone-Rod, Type 7
Retinitis Pigmentosa 7

Vitreoretinochoroidopathy

Autosomal Dominant Vitreoretinochoroidopathy	Advirc
Vitreoretinochoroidopathy With Microcornea, Glaucoma, And Cataract	Vitreoretinochoroidopathy, Autosomal Dominant, With Nanophthalmos
Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 2	Vitreoretinochoroidopathy Dominant
VRCP	Vitreoretinochoroidopathy, Autosomal Dominant
Vrcp Autosomal Dominant	Vitreoretinochoroidopathy Autosomal Dominant With Nanophthalmos, Microcornea, Rod-Cone Dystrophy, Cataract And Posterior Staphyloma
Vitreoretinochoroidopathy With Microcornea-Glaucoma-Cataract

Basal Laminar Drusen

Drusen Of Bruch Membrane	Drusen, Cuticular
Drusen, Early Adult-Onset, Grouped	Cuticular Drusen
Early Adult-Onset Grouped Drusen	BLD
Drusen Cuticular	Drusen Early Adult-Onset Grouped

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Stargardt Disease

Stargardt Disease 1	Stargardt Macular Dystrophy
Stargardt Disease-1	Juvenile Onset Macular Degeneration
Stargardt Macular Degeneration	Juvenile Macular Degeneration
Macular Dystrophy With Flecks, Type 1	Stgd
Fundus Flavimaculatus	Stargardt 1
Stargardts Disease

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06800	IMPG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IMPG1	VGNC	VGNC:104405
Mus musculus	IMPG1	MGD	MGI:1926876
Canis familiaris	IMPG1	VGNC	VGNC:42012
Rattus norvegicus	IMPG1	RGD	RGD:620499
Felis catus	IMPG1	VGNC	VGNC:67799

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