INPP5A - inositol polyphosphate-5-phosphatase A Gene

Homo sapiens

Also known as 5PTASE

Gene ID: 3632 | Gene type: protein coding

About INPP5A

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:132,537,787-132,783,480 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in heart (RPKM 7.6), testis (RPKM 4.7) and 25 other tissues.

Summary

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

INPP5A Products(2)

mRNA	Protein	Name
NM_001321042.2	NP_001307971.1	inositol polyphosphate-5-phosphatase A isoform b
NM_005539.5	NP_005530.3	inositol polyphosphate-5-phosphatase A isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PH domain binding	IPI IPI: Inferred from physical interaction	8999861	GOA
enables inositol-polyphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	8006039	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8999861	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	8006039	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8626616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INPP5A Protein Structure

Exo_endo_phos

0
100
200
300
412 a.a.

Protein Preferred Names

Protein Names

inositol polyphosphate-5-phosphatase A

43 kDa inositol polyphosphate 5-phophatase

INPP5A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	INPP5A	Q14642	PLEK	Homo sapiens	P08567	Enzymatic Study	8999861
Intra	INPP5A	Q14642	TEAD2	Homo sapiens	Q15562-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant INPP5A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70834	INPP5A Protein, Human (HEK293, His)	Q14642 (M1-V410)	≥95%

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 17

Spinocerebellar Ataxia Type 17	SCA17
Huntington Disease-Like 4	Hdl4
Olivopontocerebellar Atrophy V	Cerebelloparenchymal Disorder Ii
Opca5	Cpd2
Sca 17	Ataxia, Spinocerebellar, Type 17

Lowe Oculocerebrorenal Syndrome

Lowe Syndrome	Oculocerebrorenal Syndrome
OCRL	Oculocerebrorenal Syndrome Of Lowe
Ocrl1	Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency
Lowe Disease	Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency
Cerebrooculorenal Syndrome	Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency
Lowe Oculo-Cerebro-Renal Dystrophy	Lowe Oculo-Cerebro-Renal Syndrome
Lowe Oculocerebrorenal Dystrophy	Low
Chromosome 11p Deletion Syndrome	Oculocerebrorenal Dystrophy
Cerebro-Oculorenal Dystrophy	Ocrl1 - [Oculocerebrorenal Syndrome]
Lowe-Terrey-Maclachlan Syndrome	Renal-Oculocerebrodystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06827	INPP5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	INPP5A	RGD	RGD:1306168
Bos taurus	INPP5A	VGNC	VGNC:30210
Mus musculus	INPP5A	MGD	MGI:2686961
Macaca mulatta	INPP5A	VGNC	VGNC:73749
Canis familiaris	INPP5A	VGNC	VGNC:42030
Felis catus	INPP5A	VGNC	VGNC:67807
Others	INPP5A	NCBI

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