ISG20 - interferon stimulated exonuclease gene 20 Gene

Homo sapiens

Also known as CD25; HEM45

Gene ID: 3669 | Gene type: protein coding

About ISG20

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,635,632-88,656,483 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 5 paralogues. Biased expression in lymph node (RPKM 12.2), spleen (RPKM 8.7) and 13 other tissues.

Summary

Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

ISG20 Products(6)

mRNA	Protein	Name
NM_001303233.2	NP_001290162.1	interferon-stimulated gene 20 kDa protein isoform a
NM_001303234.2	NP_001290163.1	interferon-stimulated gene 20 kDa protein isoform a
NM_001303235.2	NP_001290164.1	interferon-stimulated gene 20 kDa protein isoform b
NM_001303236.2	NP_001290165.1	interferon-stimulated gene 20 kDa protein isoform b
NM_001303237.2	NP_001290166.1	interferon-stimulated gene 20 kDa protein isoform c
NM_002201.6	NP_002192.2	interferon-stimulated gene 20 kDa protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5'-RNA exonuclease activity	IDA IDA: Inferred from direct assay	11401564	GOA
enables U1 snRNA binding	IDA IDA: Inferred from direct assay	16514659	GOA
enables U2 snRNA binding	IDA IDA: Inferred from direct assay	16514659	GOA
enables U3 snoRNA binding	IDA IDA: Inferred from direct assay	16514659	GOA
enables exonuclease activity	IMP IMP: Inferred from mutant phenotype	21036379	GOA
enables single-stranded DNA 3'-5' DNA exonuclease activity	IDA IDA: Inferred from direct assay	11401564	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA catabolic process	IDA IDA: Inferred from direct assay	11401564	GOA
involved in RNA catabolic process	IDA IDA: Inferred from direct assay	11401564	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	21036379	GOA
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	21036379	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	12594219	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	16514659	GOA
located in PML body	IDA IDA: Inferred from direct assay	9235947	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16514659	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	16514659	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21036379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISG20 Protein Structure

RNase_T

0
100
181 a.a.

Protein Preferred Names

Protein Names

interferon-stimulated gene 20 kDa protein

estrogen-regulated transcript 45 protein

Related Diseases

Diseases

Alias

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Estrogen-Receptor Positive Breast Cancer

Subacute Delirium

Delirium

Acute Confusional State Nos

Yellow Fever

Urban Yellow Fever	Jungle Yellow Fever
Sylvatic Yellow Fever	Yf
Yellow Fever, Sylvan	Bronze John
Yellow Jack	Yf- [Yellow Fever]
Febris Flava

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06930	ISG20 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-125980	LX-3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ISG20	VGNC	VGNC:67833
Bos taurus	ISG20	VGNC	VGNC:30294
Macaca mulatta	ISG20	VGNC	VGNC:73769
Canis familiaris	ISG20	VGNC	VGNC:42107
Mus musculus	ISG20	MGD	MGI:1928895
Rattus norvegicus	ISG20	RGD	RGD:1306407

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