USP50 - ubiquitin specific peptidase 50 Gene

Homo sapiens

Gene ID: 373509 | Gene type: protein coding

About USP50

This gene has 11 transcripts (splice variants), 172 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 3.5), bone marrow (RPKM 2.9) and 25 other tissues.

Summary

Enables ubiquitin-like protein-specific Protease activity. Acts upstream of or within several processes, including nuclear speck organization; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of macromolecule metabolic process. Predicted to be active in several cellular components, including dendritic spine; midbody; and postsynaptic density. Predicted to be extrinsic component of endosome membrane and extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

USP50 Products(1)

mRNA	Protein	Name
NM_203494.5	NP_987090.2	inactive ubiquitin carboxyl-terminal hydrolase 50

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	28094437	GOA
enables ubiquitin-like protein peptidase activity	IDA IDA: Inferred from direct assay	28094437	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within nuclear speck organization	IMP IMP: Inferred from mutant phenotype	28094437	GOA
acts upstream of or within positive regulation of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	28094437	GOA
acts upstream of or within positive regulation of cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	28094437	GOA
acts upstream of or within positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	28094437	GOA
acts upstream of or within protein deubiquitination	IDA IDA: Inferred from direct assay	28094437	GOA
involved in regulation of cell cycle G2/M phase transition	IMP IMP: Inferred from mutant phenotype	20930503	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	20930503	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20930503	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20930503	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP50 Protein Structure

UCH

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

inactive ubiquitin carboxyl-terminal hydrolase 50

inactive ubiquitin-specific peptidase 50

Related Diseases

Diseases

Alias

Spondyloarthropathy 1

Ankylosing Spondylitis	Spondyloarthropathy, Susceptibility To, 1
SPDA1	Marie-Strumpell Spondylitis
Bechterew Syndrome	Spa
Spondylarthritis Ankylopoietica	Reiter Syndrome
Ankylosing Spondylitis, Susceptibility To	Bekhterev Syndrome
Bekhterev'S Disease	Marie-Strumpell Disease
Axial Spondylarthritis	Bechterew Disease
Marie-Struempell Disease	Spondylitis Ankylopoietica
Spondyloarthritis	Spondyloarthritis Ankylopoietica
Spas	Ankylosing Spondylarthritis
Psoriatic Arthritis	Reactive Arthritis
Rheumatoid Spondylitis	Spondylitis Ankylosans
Spondylitis Ankylosing	Spondylitis, Ankylosing
Spondylarthropathies	Arthritis, Psoriatic
Arthritis, Reactive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15562	USP50 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	USP50	VGNC	VGNC:55016
Rattus norvegicus	USP50	RGD	RGD:1564751
Bos taurus	USP50	VGNC	VGNC:52848
Felis catus	USP50	VGNC	VGNC:66894
Mus musculus	USP50	MGD	MGI:1922333
Macaca mulatta	USP50	VGNC	VGNC:79232
Others	USP50	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.