RAB15 - RAB15, member RAS oncogene family Gene

Homo sapiens

Gene ID: 376267 | Gene type: protein coding

About RAB15

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,945,816-64,972,336 (from NCBI)

This gene has 10 transcripts (splice variants), 264 orthologues and 68 paralogues. Broad expression in brain (RPKM 21.8), urinary bladder (RPKM 12.3) and 21 other tissues.

Summary

Predicted to enable GTP binding activity and GTPase activity. Involved in positive regulation of regulated secretory pathway. Located in cilium; endosome membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RAB15 Products(3)

mRNA	Protein	Name
NM_001308154.2	NP_001295083.1	ras-related protein Rab-15 isoform 2
NM_001330182.2	NP_001317111.1	ras-related protein Rab-15 isoform 3
NM_198686.3	NP_941959.1	ras-related protein Rab-15 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16195351	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of regulated secretory pathway	IGI IGI: Inferred from genetic interaction	22899725	GOA
involved in positive regulation of regulated secretory pathway	IMP IMP: Inferred from mutant phenotype	22899725	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	17646400	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16195351	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	16195351	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16195351	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB15 Protein Structure

Ras

0
100
200
212 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-15

RAB15, member RAS onocogene family

Related Diseases

Diseases

Alias

Immunodeficiency 54

Natural Killer Cell Deficiency, Familial Isolated	Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency
IMD54	Nkcd
Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect	Nkgcd
Familial Isolated Natural Killer Cell Deficiency	Primary Immunodeficiency Due To Mcm4 Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11524	RAB15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB15	RGD	RGD:735172
Mus musculus	RAB15	MGD	MGI:1916865
Bos taurus	RAB15	VGNC	VGNC:33623
Macaca mulatta	RAB15	VGNC	VGNC:81519
Canis familiaris	RAB15	VGNC	VGNC:45255
Felis catus	RAB15	VGNC	VGNC:104611

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