KCNJ9 - potassium inwardly rectifying channel subfamily J member 9 Gene

Homo sapiens

Also known as GIRK3; KIR3.3

Gene ID: 3765 | Gene type: protein coding

About KCNJ9

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,081,538-160,090,563 (from NCBI)

This gene has 1 transcript (splice variant), 186 orthologues and 15 paralogues. Restricted expression toward brain (RPKM 8.9).

Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type Potassium Channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated Potassium Channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]

KCNJ9 Products(1)

mRNA	Protein	Name
NM_004983.3	NP_004974.2	G protein-activated inward rectifier potassium channel 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12297500	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNJ9 Protein Structure

IRK

0
100
200
300
393 a.a.

Protein Preferred Names

Protein Names

G protein-activated inward rectifier potassium channel 3

G protein-coupled inward rectifier potassium channel

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 7

DFNA7	Autosomal Dominant Nonsyndromic Deafness 7
Autosomal Dominant Deafness 7	Deafness, Autosomal Dominant, 7
Deafness, Autosomal Dominant, Type 7

Vitreoretinal Degeneration, Snowflake Type

Snowflake Vitreoretinal Degeneration	SVD
Snowflake Degeneration In Hereditary Vitreoretinal Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07151	KCNJ9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KCNJ9	VGNC	VGNC:30464
Canis familiaris	KCNJ9	VGNC	VGNC:42269
Felis catus	KCNJ9	VGNC	VGNC:67918
Macaca mulatta	KCNJ9	VGNC	VGNC:106397
Rattus norvegicus	KCNJ9	RGD	RGD:621440
Mus musculus	KCNJ9	MGD	MGI:108007

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