ARF3 - ADP ribosylation factor 3 Gene

Homo sapiens

Gene ID: 377 | Gene type: protein coding

About ARF3

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,935,723-48,957,487 (from NCBI)

This gene has 10 transcripts (splice variants), 253 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 69.0), colon (RPKM 28.8) and 24 other tissues.

Summary

ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of Phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute one family of the Ras superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. [provided by RefSeq, Oct 2022]

ARF3 Products(11)

mRNA	Protein	Name
NM_001412914.1	NP_001399843.1	ADP-ribosylation factor 3 isoform a
NM_001412915.1	NP_001399844.1	ADP-ribosylation factor 3 isoform a
NM_001412916.1	NP_001399845.1	ADP-ribosylation factor 3 isoform a
NM_001412918.1	NP_001399847.1	ADP-ribosylation factor 3 isoform a
NM_001412920.1	NP_001399849.1	ADP-ribosylation factor 3 isoform a
NM_001412926.1	NP_001399855.1	ADP-ribosylation factor 3 isoform a
NM_001412928.1	NP_001399857.1	ADP-ribosylation factor 3 isoform a
NM_001412930.1	NP_001399859.1	ADP-ribosylation factor 3 isoform a
NM_001412931.1	NP_001399860.1	ADP-ribosylation factor 3 isoform a
NM_001412932.1	NP_001399861.1	ADP-ribosylation factor 3 isoform b
NM_001659.3	NP_001650.1	ADP-ribosylation factor 3 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IGI IGI: Inferred from genetic interaction	24768165	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARF3 Protein Structure

Arf

0
100
181 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor 3

small GTP binding protein

Recombinant ARF3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75583	ARF3 Protein, Human (His)	P61204 (M1-K181)	≥95%

Related Diseases

Diseases

Alias

Pectus Excavatum

Funnel Chest

Congenital Pectus Excavatum

Scoliosis

Heart, Malformation Of

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Hypotonia

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia	SMC1
Smc	Smith Mccort Dysplasia
Smith-Mccort Dwarfism

Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18	RP7
Retinitis Pigmentosa 7, Digenic Form	Retinitis Pigmentosa 7 And Digenic Form
Retinitis Pigmentosa 7, Digenic	LCA18
Retinitis Pigmentosa 7 Digenic

Dyggve-Melchior-Clausen Disease

Dyggve-Melchior-Clausen Syndrome	DMC
Dmc Disease	Pseudo-Morquio Disease Type I
Dmc Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00895	ARF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARF3	RGD	RGD:621273
Felis catus	ARF3	VGNC	VGNC:83498
Mus musculus	ARF3	MGD	MGI:99432
Others	ARF3	NCBI

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