KCNK2 - potassium two pore domain channel subfamily K member 2 Gene

Homo sapiens

Also known as TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e

Gene ID: 3776 | Gene type: protein coding

About KCNK2

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:215,005,542-215,237,090 (from NCBI)

This gene has 9 transcripts (splice variants), 282 orthologues and 14 paralogues. Biased expression in adrenal (RPKM 18.5), thyroid (RPKM 2.6) and 1 other tissue.

Summary

This gene encodes one of the members of the two-pore-domain background Potassium Channel protein family. This type of Potassium Channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

KCNK2 Products(3)

mRNA	Protein	Name
NM_001017424.3	NP_001017424.1	potassium channel subfamily K member 2 isoform a
NM_001017425.3	NP_001017425.2	potassium channel subfamily K member 2 isoform c
NM_014217.4	NP_055032.1	potassium channel subfamily K member 2 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables mechanosensitive potassium channel activity	IDA IDA: Inferred from direct assay	38605031	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNK2 Protein Structure

Ion_trans_2

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

potassium channel subfamily K member 2

K2P2.1 potassium channel

Related Diseases

Diseases

Alias

Dentin Sensitivity

Sensitive Dentin

Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome	BIBARS
Mental Retardation With Hypotonia And Facial Dysmorphism	Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome
Kcnk9 Imprinting Syndrome

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2x

Lgmd2x

Muscular Dystrophy, Limb-Girdle, Type 2x

Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

Dehydrated Hereditary Stomatocytosis	Hereditary Xerocytosis
Xerocytosis, Hereditary	Pshk1
Pseudohyperkalemia Edinburgh	Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema
DHS1	Dhs
Hereditary Desiccytosis	Dehydrated Hereditary Stomatocytosis 1
Desiccytosis, Hereditary	Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak
Pseudohyperkalemia Familial 1, Due To Red Cell Leak	Desiccytosis Hereditary
Xerocytosis Hereditary	Familial Pseudohyperkalemia 1 Due To Red Cell Leak
Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema	Xerocytosis

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1500	2,2,2-Trichloroethanol	Agonist	99.53%	Unkown
HY-RS07158	KCNK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KCNK2	RGD	RGD:621448
Bos taurus	KCNK2	VGNC	VGNC:30472
Macaca mulatta	KCNK2	VGNC	VGNC:99988
Felis catus	KCNK2	VGNC	VGNC:67920
Mus musculus	KCNK2	MGD	MGI:109366
Canis familiaris	KCNK2	VGNC	VGNC:42274

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