ENTPD8 - ectonucleoside triphosphate diphosphohydrolase 8 Gene

Homo sapiens

Also known as UNQ2492; GLSR2492; E-NTPDase; NTPDase-8

Gene ID: 377841 | Gene type: protein coding

About ENTPD8

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,434,364-137,441,357 (from NCBI)

This gene has 4 transcripts (splice variants), 171 orthologues and 7 paralogues. Biased expression in colon (RPKM 14.4), duodenum (RPKM 11.4) and 6 other tissues.

Summary

Predicted to enable guanosine-diphosphatase activity and uridine-diphosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Predicted to act upstream of or within nucleoside diphosphate biosynthetic process and nucleoside monophosphate biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ENTPD8 Products(2)

mRNA	Protein	Name
NM_001033113.2	NP_001028285.1	ectonucleoside triphosphate diphosphohydrolase 8 isoform 1
NM_198585.3	NP_940987.2	ectonucleoside triphosphate diphosphohydrolase 8 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENTPD8 Protein Structure

GDA1_CD39

0
100
200
300
400
495 a.a.

Protein Preferred Names

Protein Names

ectonucleoside triphosphate diphosphohydrolase 8

E-NTPDase 8

Related Diseases

Diseases

Alias

Spastic Paraplegia 64, Autosomal Recessive

SPG64	Hereditary Spastic Paraplegia 64
Autosomal Recessive Spastic Paraplegia Type 64	Autosomal Recessive Spastic Paraplegia 64
Paraplegia, Spastic, Type 64, Autosomal Recessive

Vasculogenic Impotence

Impotence, Vasculogenic

Trichomoniasis

Trichomonas Infection	Trichomonas Infections
Disease Due To Trichomonadidae	Infection By Trichomonas
Trichomonadosis	Trichomonas Pruritus
Trichomonosis	Tricomoniasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04401	ENTPD8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ENTPD8	VGNC	VGNC:28513
Mus musculus	ENTPD8	MGD	MGI:1919340
Canis familiaris	ENTPD8	VGNC	VGNC:40386
Felis catus	ENTPD8	VGNC	VGNC:61884
Macaca mulatta	ENTPD8	VGNC	VGNC:72104
Rattus norvegicus	ENTPD8	RGD	RGD:1561793

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