KCNS1 - potassium voltage-gated channel modifier subfamily S member 1 Gene

Homo sapiens

Also known as Kv9.1

Gene ID: 3787 | Gene type: protein coding

About KCNS1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,091,214-45,101,127 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues and 31 paralogues. Biased expression in brain (RPKM 2.8), gall bladder (RPKM 1.3) and 3 other tissues.

Summary

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly Other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the Potassium Channel family. [provided by RefSeq, Jul 2008]

KCNS1 Products(2)

mRNA	Protein	Name
NM_001322799.2	NP_001309728.1	potassium voltage-gated channel subfamily S member 1
NM_002251.5	NP_002242.2	potassium voltage-gated channel subfamily S member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	10484328	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10484328	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	10484328	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	10484328	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	10484328	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNS1 Protein Structure

BTB_2

Ion_trans

0
100
200
300
400
526 a.a.

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily S member 1

delayed-rectifier K(+) channel alpha subunit 1

Related Diseases

Diseases

Alias

Causalgia

Complex Regional Pain Syndrome, Type Ii

Complex Regional Pain Syndrome Type 2

Paroxysmal Extreme Pain Disorder

PEPD	Familial Rectal Pain
Pexpd	Submandibular, Ocular, And Rectal Pain With Flushing
Pain, Submandibular, Ocular, And Rectal, With Flushing	Rectal Pain, Familial
Submandibular, Ocular And Rectal Pain With Flushing	Familial Rectal Syndrome
Frp	Pain Disorder, Paroxysmal, Extreme

Erythromelalgia

Primary Erythromelalgia	Erythermalgia
Primary Erythermalgia	Mitchell Disease
Familial Erythromelalgia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07179	KCNS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-123009	KCN1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KCNS1	VGNC	VGNC:30491
Mus musculus	KCNS1	MGD	MGI:1197019
Rattus norvegicus	KCNS1	RGD	RGD:621524
Felis catus	KCNS1	VGNC	VGNC:67932
Canis familiaris	KCNS1	VGNC	VGNC:42293
Macaca mulatta	KCNS1	VGNC	VGNC:84919

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