KIR2DL1 - killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Gene

Homo sapiens

Also known as NKAT; NKAT1; p58.1; CD158A; KIR221; NKAT-1; KIR-K64; KIR2DL3

Gene ID: 3802 | Gene type: protein coding

About KIR2DL1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,769,793-54,784,322 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 55 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

KIR2DL1 Products(1)

mRNA	Protein	Name
NM_014218.3	NP_055033.2	killer cell immunoglobulin-like receptor 2DL1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8691146	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in natural killer cell inhibitory signaling pathway	IDA IDA: Inferred from direct assay	18604210	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	18604210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIR2DL1 Protein Structure

0
100
200
300
348 a.a.

Protein Preferred Names

Protein Names

killer cell immunoglobulin-like receptor 2DL1

CD158 antigen-like family member A

KIR2DL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KIR2DL1	P43626	HLA-B	Homo sapiens	P01889	Affinity Chrom	28546555
Intra	KIR2DL1	P43626	HLA-C	Homo sapiens	P10321	FACS	18624290
Intra	KIR2DL1	P43626	HLA-C	Homo sapiens	P10321	Affinity Chrom	19858347
Intra	KIR2DL1	P43626	HLA-C	Homo sapiens	P10321	Affinity Chrom	28546555
Intra	KIR2DL1	P43626	HLA-Cw	Homo sapiens	Q5RIP0	Affinity Chrom	18322206
Intra	KIR2DL1	P43626	HLA-C	Homo sapiens	Q7YQB1	Affinity Chrom	18322206

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KIR2DL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74792	KIR2DL1 Protein, Human (HEK293, Fc)	P43626-1/NP_055033.2 (H22-H245)	≥95%
HY-P74793	KIR2DL1 Protein, Human (HEK293, His)	P43626-1/NP_055033.2 (H22-H245)	≥95%
HY-P78165	KIR2DL1 Protein, Human (Biotinylated, HEK293, His-Avi)	P43626-1 (H22-R242)	≥95%
HY-P78473	KIR2DL1 Protein, Human (HEK293, His-Avi)	P43626-1 (H22-R242)	≥95%

Related Diseases

Diseases

Alias

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Chronic Nk-Cell Lymphocytosis

Nk-Cell Large Granular Lymphocyte Lymphocytosis

Chronic Lymphoproliferative Disorder Of Nk-Cells

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07301	KIR2DL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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