KIF22 - kinesin family member 22 Gene

Homo sapiens

Also known as KID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2

Gene ID: 3835 | Gene type: protein coding

About KIF22

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,790,751-29,805,385 (from NCBI)

This gene has 33 transcripts (splice variants), 179 orthologues, 41 paralogues and is associated with 3 phenotypes. Broad expression in bone marrow (RPKM 24.9), testis (RPKM 13.3) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

KIF22 Products(3)

mRNA	Protein	Name
NM_001256269.2	NP_001243198.1	kinesin-like protein KIF22 isoform 2
NM_001256270.1	NP_001243199.1	kinesin-like protein KIF22 isoform 2
NM_007317.3	NP_015556.1	kinesin-like protein KIF22 isoform 1

KIF22 Protein Structure

Kinesin

HHH_3

0
200
400
600
665 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF22

kinesin-like DNA-binding protein pseudogene

KIF22 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82753	Phospho-KIF22 (Ser427) Antibody (YA2498)	WB	Human

Related Diseases

Diseases

Alias

Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2

SEMDJL2	Spondyloepimetaphyseal Dysplasia With Joint Laxity, Leptodactylic Type
Spondyloepimetaphyseal Dysplasia With Multiple Dislocations, Hall Type	Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2
Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Hall Type	Spondyloepimetaphyseal Dysplasia With Joint Laxity, Hall Type
Semd-Md	Spondyloepimetaphyseal Dysplasia With Joint Laxicity, Hall Type
Spondyloepimetaphyseal Dysplasia With Joint Laxity, 2	Lepto-Semdjl
Spondyloepimetaphyseal Dysplasia With Joint Laxity Hall Type	Spondyloepimetaphyseal Dysplasia With Joint Laxity Leptodactylic Type
Spondyloepimetaphyseal Dysplasia With Multiple Dislocations

Spondyloepimetaphyseal Dysplasia With Multiple Dislocations

Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Hall Type	Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Leptodactylic Type
Semd-Md	Semdjl2
Spondyloepimetaphyseal Dysplasia With Joint Laxicity, Hall Type	Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Leptodactylic Type	Spondyloepimetaphyseal Dysplasia With Multiple Dislocations, Hall Type

Spondyloepimetaphyseal Dysplasia With Joint Laxity

Dysplasia, Spondyloepimetaphyseal, With Joint Laxity	Semdjl
Spondyloepimetaphyseal Dysplasia Joint Laxity	Semd-Jl
Semdjl1	Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 1
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Beighton Type

Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal

Spondylocostal Dysostosis 5

Spondylothoracic Dysostosis	SCDO5
Jarcho-Levin Syndrome	Scoliosis, Congenital, With Or Without Rib Anomalies
Tacs	Spondylocostal Dysplasia
Costovertebral Segmentation Anomalies	Spondylocostal Dysostosis 1
Spondylocostal Dysostosis	Spondylothoracic Dysplasia
Scdo1	Spondylocostal Dysostosis 1 Autosomal Recessive
Costovertebral Dysplasia	Scdo
Std	Autosomal Dominant Spondylocostal Dysostosis
Autosomal Dominant Spondylocostal Dysplasia	Doid:0112363
Spondylocostal Dysostosis 4, Autosomal Dominant

Bone Disease

Bone Diseases	Skeletal Disease
Skeletal Disorder	Disorder Of Skeletal System

Spondylocostal Dysostosis

Jarcho-Levin Syndrome	Costovertebral Dysplasia
Spondylothoracic Dysostosis	Spondylothoracic Dysplasia
Scdo	Dysostosis, Spondylocostal

Scoliosis

Benign Familial Infantile Epilepsy

Benign Familial Infantile Seizures	Bfie
Benign Familial Infantile Convulsion	Bfic
Bfis	Benign Familial Infantile Convulsions
Familial Benign Neonatal Epilepsy	Watanabe-Vigevano Syndrome

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07276	KIF22 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KIF22	VGNC	VGNC:30596
Canis familiaris	KIF22	VGNC	VGNC:42398
Felis catus	KIF22	VGNC	VGNC:67973
Rattus norvegicus	KIF22	RGD	RGD:1311886
Mus musculus	KIF22	MGD	MGI:109233
Macaca mulatta	KIF22	VGNC	VGNC:74033

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