SLC9A4 - solute carrier family 9 member A4 Gene

Homo sapiens

Also known as NHE4

Gene ID: 389015 | Gene type: protein coding

About SLC9A4

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,473,226-102,533,972 (from NCBI)

This gene has 2 transcripts (splice variants), 134 orthologues and 10 paralogues. Biased expression in stomach (RPKM 24.9) and kidney (RPKM 5.2).

Summary

Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within epithelial cell development and gastric acid secretion. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and vacuolar membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC9A4 Products(1)

mRNA	Protein	Name
NM_001011552.4	NP_001011552.2	sodium/hydrogen exchanger 4 precursor

SLC9A4 Protein Structure

Na_H_Exchanger

0
200
400
600
798 a.a.

Protein Preferred Names

Protein Names

sodium/hydrogen exchanger 4

NHE-4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13344	SLC9A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC9A4	VGNC	VGNC:34943
Mus musculus	SLC9A4	MGD	MGI:105074
Felis catus	SLC9A4	VGNC	VGNC:65435
Macaca mulatta	SLC9A4	VGNC	VGNC:77641
Rattus norvegicus	SLC9A4	RGD	RGD:3721
Canis familiaris	SLC9A4	VGNC	VGNC:108217

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