VGLL3 - vestigial like family member 3 Gene

Homo sapiens

Also known as VGL3; VGL-3

Gene ID: 389136 | Gene type: protein coding

About VGLL3

Cytogenetic location: 3p12.1 Genomic coordinates (GRCh38): 3:86,937,973-86,991,149 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 2 paralogues. Biased expression in placenta (RPKM 19.8), fat (RPKM 7.7) and 12 other tissues.

Summary

Predicted to enable protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

VGLL3 Products(3)

mRNA	Protein	Name
NM_001320493.2	NP_001307422.1	transcription cofactor vestigial-like protein 3 isoform 2
NM_001320494.2	NP_001307423.1	transcription cofactor vestigial-like protein 3 isoform 3
NM_016206.4	NP_057290.2	transcription cofactor vestigial-like protein 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VGLL3 Protein Structure

Vg_Tdu

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

transcription cofactor vestigial-like protein 3

colon carcinoma related protein

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 48

RP48	Retinitis Pigmentosa, Type 48

Childhood Supratentorial Ependymoma

Paediatric Cerebral Ependymoma	Paediatric Supratentorial Ependymoblastoma
Paediatric Supratentorial Ependymoma	Pediatric Cerebral Ependymoma
Pediatric Supratentorial Ependymoblastoma	Pediatric Supratentorial Ependymoma

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15646	VGLL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VGLL3	VGNC	VGNC:48259
Macaca mulatta	VGLL3	VGNC	VGNC:79430
Mus musculus	VGLL3	MGD	MGI:1920819
Rattus norvegicus	VGLL3	RGD	RGD:1560030
Bos taurus	VGLL3	VGNC	VGNC:36792
Felis catus	VGLL3	VGNC	VGNC:66941

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