ALKAL1 - ALK and LTK ligand 1 Gene

Homo sapiens

Also known as AUGA; AUGB; FAM150A; UNQ9433

Gene ID: 389658 | Gene type: protein coding

About ALKAL1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:52,534,037-52,565,430 (from NCBI)

This gene has 2 transcripts (splice variants) and 161 orthologues. Biased expression in gall bladder (RPKM 1.3), thyroid (RPKM 1.1) and 7 other tissues.

Summary

Enables receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of ERK5 cascade; and positive regulation of neuron projection development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

ALKAL1 Products(1)

mRNA	Protein	Name
NM_207413.4	NP_997296.1	ALK and LTK ligand 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	34646012	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26418745	GOA
enables receptor signaling protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	26418745	GOA
enables receptor tyrosine kinase binding	IDA IDA: Inferred from direct assay	26418745	GOA
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	34646012	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	34646012	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	26418745	GOA
involved in positive regulation of ERK5 cascade	IDA IDA: Inferred from direct assay	26418745	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	26418745	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	34646012	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKAL1 Protein Structure

FAM150

0
100
129 a.a.

Protein Preferred Names

Protein Names

ALK and LTK ligand 1

AUG-beta

ALKAL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALKAL1	Q6UXT8	ALK	Homo sapiens	Q9UM73	Anti Tag CoIP	26418745
Intra	ALKAL1	Q6UXT8	ALK	Homo sapiens	Q9UM73	SPR	26418745
Intra	ALKAL1	Q6UXT8	ALK	Homo sapiens	Q9UM73	Anti Bait CoIP	26418745
Intra	ALKAL1	Q6UXT8	ALK	Homo sapiens	Q9UM73	ELISA	26418745
Intra	ALKAL1	Q6UXT8	ALK	Homo sapiens	Q9UM73	IF	26418745
Intra	ALKAL1	Q6UXT8	LTK	Homo sapiens	P29376	Anti Tag CoIP	26418745

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALKAL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71584	ALKAL1 Protein, Human (His, B2M)	Q6UXT8 (R28-T129)	≥95%

Related Diseases

Diseases

Alias

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00601	ALKAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ALKAL1	VGNC	VGNC:83979
Mus musculus	ALKAL1	MGD	MGI:3645495
Canis familiaris	ALKAL1	VGNC	VGNC:49887
Felis catus	ALKAL1	VGNC	VGNC:105869
Rattus norvegicus	ALKAL1	RGD	RGD:1583530
Others	ALKAL1	NCBI

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