LTK - leukocyte receptor tyrosine kinase Gene

Homo sapiens

Also known as TYK1

Gene ID: 4058 | Gene type: protein coding

About LTK

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,503,637-41,513,827 (from NCBI)

This gene has 6 transcripts (splice variants), 62 orthologues and 53 paralogues. Broad expression in duodenum (RPKM 6.4), lung (RPKM 6.1) and 15 other tissues.

Summary

The protein encoded by this gene is a member of the ros/Insulin Receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

LTK Products(3)

mRNA	Protein	Name
NM_001135685.2	NP_001129157.1	leukocyte tyrosine kinase receptor isoform 3 precursor
NM_002344.6	NP_002335.2	leukocyte tyrosine kinase receptor isoform 1 precursor
NM_206961.4	NP_996844.1	leukocyte tyrosine kinase receptor isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9223670	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	10445845	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	7650032	GOA
enables receptor signaling protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	30061385	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	30061385	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell population proliferation	IDA IDA: Inferred from direct assay	10445845	GOA
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	30061385	GOA
involved in cell surface receptor protein tyrosine kinase signaling pathway	IMP IMP: Inferred from mutant phenotype	9223670	GOA
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	9223670	GOA
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	30061385	GOA
involved in positive regulation of cardiac muscle cell apoptotic process	IDA IDA: Inferred from direct assay	10445845	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	9223670	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	10445845	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	34646012	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTK Protein Structure

Gly_rich

Pkinase_Tyr

0
200
400
600
800
864 a.a.

Protein Preferred Names

Protein Names

leukocyte tyrosine kinase receptor

protein tyrosine kinase 1

LTK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LTK	P29376	ALKAL1	Homo sapiens	Q6UXT8	Anti Tag CoIP	26418745
Intra	LTK	P29376	ALKAL1	Homo sapiens	Q6UXT8	ELISA	26418745
Intra	LTK	P29376	EPHA2	Homo sapiens	P29317	BioID	35384245
Intra	LTK	P29376	EPHA2	Homo sapiens	P29317	Affinity Chrom	35384245
Intra	LTK	P29376	EPHA2	Homo sapiens	P29317	Anti Tag CoIP	35384245
Intra	LTK	P29376	PIK3R1	Homo sapiens	P27986	BioID	35384245
Intra	LTK	P29376	PIK3R1	Homo sapiens	P27986	Affinity Chrom	35384245

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Her2-Receptor Positive Breast Cancer

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155516	KV1.3-IN-1	Inhibitor	98.34%	Unkown
HY-131909	CJ-2360	Inhibitor	/	Unkown
HY-108263B	(R)-3-Hydroxy Midostaurin	Inhibitor	/	Unkown
HY-110347	Mps1-IN-1 dihydrochloride	Inhibitor	/	Unkown
HY-145256	GABAA receptor agent 4	Antagonist	/	Unkown
HY-145257	GABAA receptor agent 5	Antagonist	/	Unkown
HY-15018A	SSR126768A free base	Antagonist	/	Unkown
HY-RS07884	LTK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LTK	VGNC	VGNC:84372
Mus musculus	LTK	MGD	MGI:96840
Rattus norvegicus	LTK	RGD	RGD:1309323
Others	LTK	NCBI

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