LCP1 - lymphocyte cytosolic protein 1 Gene

Homo sapiens

Also known as LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN

Gene ID: 3936 | Gene type: protein coding

About LCP1

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:46,125,923-46,182,177 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 63 phenotypes. Broad expression in lymph node (RPKM 278.7), bone marrow (RPKM 256.8) and 18 other tissues.

Summary

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all Other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]

LCP1 Products(1)

mRNA	Protein	Name
NM_002298.5	NP_002289.2	plastin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	24337748	GOA
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	16636079	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	20183869	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell activation involved in immune response	IDA IDA: Inferred from direct assay	17294403	GOA
involved in actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	16636079	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	16636079	GOA
involved in extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	24236012	GOA
involved in positive regulation of podosome assembly	IMP IMP: Inferred from mutant phenotype	24236012	GOA
involved in protein kinase A signaling	IMP IMP: Inferred from mutant phenotype	16636079	GOA
involved in regulation of intracellular protein transport	IDA IDA: Inferred from direct assay	17294403	GOA
NOT involved in wound healing, spreading of cells	IMP IMP: Inferred from mutant phenotype	16636079	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament	IMP IMP: Inferred from mutant phenotype	16636079	GOA
located in actin filament bundle	IMP IMP: Inferred from mutant phenotype	16636079	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16636079	GOA
located in cytosol	IDA IDA: Inferred from direct assay	2111166	GOA
located in filopodium	IMP IMP: Inferred from mutant phenotype	16636079	GOA
located in focal adhesion	IMP IMP: Inferred from mutant phenotype	16636079	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20183869	GOA
located in podosome	IDA IDA: Inferred from direct assay	24236012	GOA
located in ruffle	IMP IMP: Inferred from mutant phenotype	16636079	GOA
colocalizes with stress fiber	IMP IMP: Inferred from mutant phenotype	16636079	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCP1 Protein Structure

EF-hand_7

0
100
200
300
400
500
627 a.a.

Protein Preferred Names

Protein Names

plastin-2

L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)

Recombinant LCP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71750	LCP1 Protein, Human (P.pastoris, His)	P13796 (A2-V627)	≥95%

Related Diseases

Diseases

Alias

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

B-Cell Non-Hodgkin Lymphoma

B-Cell Nhl

B-Cell Non-Hodgkins Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07563	LCP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LCP1	MGD	MGI:104808
Canis familiaris	LCP1	VGNC	VGNC:42614
Rattus norvegicus	LCP1	RGD	RGD:1308288
Bos taurus	LCP1	VGNC	VGNC:30817
Felis catus	LCP1	VGNC	VGNC:68024
Macaca mulatta	LCP1	VGNC	VGNC:74242
Others	LCP1	NCBI

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