2. Gene
  3. ARHGDIB - Rho GDP dissociation inhibitor beta Gene

ARHGDIB - Rho GDP dissociation inhibitor beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2

Gene ID: 397 | Gene type: protein coding

About ARHGDIB

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:14,942,015-14,961,601 (from NCBI)

This gene has 9 transcripts (splice variants), 130 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 324.5), lymph node (RPKM 244.8) and 19 other tissues.

Summary

Members of the Rho (or ARH) protein family (see MIM 165390) and Other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

ARHGDIB Products(5)

mRNA Protein Name
NM_001175.7 NP_001166.3 rho GDP-dissociation inhibitor 2
NM_001321420.2 NP_001308349.1 rho GDP-dissociation inhibitor 2
NM_001321421.2 NP_001308350.1 rho GDP-dissociation inhibitor 2
NM_001321422.1 NP_001308351.1 rho GDP-dissociation inhibitor 2
NM_001321423.1 NP_001308352.1 rho GDP-dissociation inhibitor 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activity IMP
IMP: Inferred from mutant phenotype
24554735 GOA
enables Rho GDP-dissociation inhibitor activity IDA
IDA: Inferred from direct assay
7512369 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7512369 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
7512369 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of trophoblast cell migration IDA
IDA: Inferred from direct assay
24554735 GOA
involved in regulation of Rho protein signal transduction IDA
IDA: Inferred from direct assay
7512369 GOA
involved in regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
8262133 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
10802295 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGDIB Protein Structure

Rho_GDI

Rho_GDI: RHO protein GDP dissociation inhibitor (7 - 198)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

rho GDP-dissociation inhibitor 2

Rho GDI 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00944 ARHGDIB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ARHGDIB VGNC VGNC:83499
Rattus norvegicus ARHGDIB RGD RGD:1305383
Bos taurus ARHGDIB VGNC VGNC:26102
Mus musculus ARHGDIB MGD MGI:101940
Canis familiaris ARHGDIB VGNC VGNC:38070
Macaca mulatta ARHGDIB VGNC VGNC:108322