LLGL2 - LLGL scribble cell polarity complex component 2 Gene

Homo sapiens

Also known as HGL; LGL2; Hugl-2

Gene ID: 3993 | Gene type: protein coding

About LLGL2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,525,002-75,575,209 (from NCBI)

This gene has 22 transcripts (splice variants), 209 orthologues and 3 paralogues. Broad expression in stomach (RPKM 24.5), colon (RPKM 24.0) and 22 other tissues.

Summary

The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LLGL2 Products(3)

mRNA	Protein	Name
NM_001015002.2	NP_001015002.1	LLGL scribble cell polarity complex component 2 isoform b
NM_001031803.2	NP_001026973.1	LLGL scribble cell polarity complex component 2 isoform c
NM_004524.3	NP_004515.2	LLGL scribble cell polarity complex component 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	12725730	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12725730	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-leucine transport	IMP IMP: Inferred from mutant phenotype	30996345	GOA
involved in regulation of establishment or maintenance of cell polarity	IDA IDA: Inferred from direct assay	12725730	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15632202	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LLGL2 Protein Structure

LLGL

WD40

0
200
400
600
800
1020 a.a.

Protein Preferred Names

Protein Names

LLGL scribble cell polarity complex component 2

LLGL2, scribble cell polarity complex component

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07701	LLGL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LLGL2	VGNC	VGNC:68061
Canis familiaris	LLGL2	VGNC	VGNC:42705
Rattus norvegicus	LLGL2	RGD	RGD:1560307
Mus musculus	LLGL2	MGD	MGI:1918843
Macaca mulatta	LLGL2	VGNC	VGNC:99166
Bos taurus	LLGL2	VGNC	VGNC:30916

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