Flrt2 - fibronectin leucine rich transmembrane protein 2 Gene

Mus musculus

Gene ID: 399558 | Gene type: protein coding

About Flrt2

Summary

Enables chemorepellent activity and Fibroblast Growth Factor receptor binding activity. Involved in basement membrane organization; cell adhesion involved in heart morphogenesis; and Fibroblast Growth Factor receptor signaling pathway. Acts upstream of or within axon guidance; positive regulation of synapse assembly; and regulation of neuron migration. Located in cell-cell junction and extracellular space. Is integral component of plasma membrane. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system epithelium; branchial arch; central nervous system; embryo mesenchyme; and sensory organ. Orthologous to human FLRT2 (fibronectin leucine rich transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Flrt2 Products(1)

mRNA	Protein	Name
NM_201518.4	NP_958926.1	leucine-rich repeat transmembrane protein FLRT2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemorepellent activity	IDA IDA: Inferred from direct assay	21673655	MGI
enables fibroblast growth factor receptor binding	IPI IPI: Inferred from physical interaction	16872596	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21673655	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IGI IGI: Inferred from genetic interaction	21673655	MGI
involved in basement membrane organization	IMP IMP: Inferred from mutant phenotype	21350012	MGI
involved in cell adhesion involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	21350012	MGI
involved in fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16872596	MGI
involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	21350012	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	24613359	MGI
acts upstream of or within regulation of neuron migration	IGI IGI: Inferred from genetic interaction	21673655	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	16872596	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	21673655	MGI
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	16872596	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	34744626	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16872596	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	34744626	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	34744626	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leucine-rich repeat transmembrane protein FLRT2

Recombinant Flrt2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76934	FLRT2 Protein, Mouse (HEK293, His)	Q8BLU0 (C36-S539)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04985	FLRT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flrt2	NCBI	NCBI:23768

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