ARL1 - ADP ribosylation factor like GTPase 1 Gene

Homo sapiens

Also known as ARFL1

Gene ID: 400 | Gene type: protein coding

About ARL1

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,393,116-101,407,820 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues and 30 paralogues. Ubiquitous expression in thyroid (RPKM 47.8), prostate (RPKM 38.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a Phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

ARL1 Products(2)

mRNA	Protein	Name
NM_001177.6	NP_001168.1	ADP-ribosylation factor-like protein 1 isoform 1
NM_001301068.1	NP_001287997.1	ADP-ribosylation factor-like protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	9624189	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	8798635	GOA
enables enzyme activator activity	IDA IDA: Inferred from direct assay	9624189	GOA
enables phospholipase D activator activity	IDA IDA: Inferred from direct assay	9624189	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22981988	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	14580338	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein localization to Golgi apparatus	IMP IMP: Inferred from mutant phenotype	19224922	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	19224922	GOA
involved in toxin metabolic process	IDA IDA: Inferred from direct assay	9624189	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19224922	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	17488291	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL1 Protein Structure

Arf

0
100
181 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 1

ADP-ribosylation factor-like 1

Related Diseases

Diseases

Alias

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Spondyloepiphyseal Dysplasia Congenita

SEDC	Sed Congenita
Spondyloepiphyseal Dysplasia, Congenital Type	Late Spondyloepiphyseal Dysplasia
Sed, Congenital Type	Congenital Spondyloepiphyseal Dysplasia
Spranger-Wiedemann Disease	Spondyloepiphyseal Dysplasia Congenital Type
Dysplasia, Spondyloepiphyseal, Congenita	Spondyloepiphyseal Dysplasia, Congenita
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W012017	2-Hydroxytetradecanoic acid	Inhibitor	99.91%	Unkown
HY-RS00977	ARL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARL1	MGD	MGI:99436
Canis familiaris	ARL1	VGNC	VGNC:38104
Rattus norvegicus	ARL1	RGD	RGD:621326
Macaca mulatta	ARL1	VGNC	VGNC:70016
Bos taurus	ARL1	VGNC	VGNC:26135
Felis catus	ARL1	VGNC	VGNC:68201

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