1. Gene
  2. FSIP2 - fibrous sheath interacting protein 2 Gene

FSIP2 - fibrous sheath interacting protein 2 Gene

Homo sapiens

Also known as SPGF34

Gene ID: 401024 | Gene type: protein coding

About FSIP2

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:185,737,134-185,833,290 (from NCBI)

This gene has 5 transcripts (splice variants), 121 orthologues and is associated with 2 phenotypes. Biased expression in testis (RPKM 4.0), stomach (RPKM 1.4) and 2 other tissues.

Summary

This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016]

FSIP2 Products(1)

mRNA Protein Name
NM_173651.4 NP_775922.3 fibrous sheath-interacting protein 2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive effect flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
30745215 GOA
acts upstream of or within positive effect protein localization to cilium IMP
IMP: Inferred from mutant phenotype
30137358 GOA
involved in protein localization to cilium IMP
IMP: Inferred from mutant phenotype
30745215 GOA
acts upstream of or within positive effect sperm axoneme assembly IMP
IMP: Inferred from mutant phenotype
30137358 GOA
Cellular Component GO Annotation Evidence Reference Source
located in sperm end piece IDA
IDA: Inferred from direct assay
30745215 GOA
located in sperm head-tail coupling apparatus IDA
IDA: Inferred from direct assay
30745215 GOA
located in sperm midpiece IDA
IDA: Inferred from direct assay
30745215 GOA
located in sperm principal piece IMP
IMP: Inferred from mutant phenotype
30745215 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibrous sheath-interacting protein 2

Related Diseases

Diseases Alias
Spermatogenic Failure 34

SPGF34

Non-Syndromic Male Infertility Due To Sperm Motility Disorder

Non-Syndromic Male Infertility Due Asthenozoospermia

Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism

Infertility
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FSIP2 RGD RGD:1593013
Bos taurus FSIP2 VGNC VGNC:56115
Mus musculus FSIP2 MGD MGI:2664111
Canis familiaris FSIP2 VGNC VGNC:53095