2. Gene
  3. KPNA7 - karyopherin subunit alpha 7 Gene

KPNA7 - karyopherin subunit alpha 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IPOA8

Gene ID: 402569 | Gene type: protein coding

About KPNA7

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,145,804-99,219,419 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 193 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in stomach (RPKM 1.6), gall bladder (RPKM 0.1) and 3 other tissues.

Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Jul 2016]

KPNA7 Products(1)

mRNA Protein Name
NM_001145715.3 NP_001139187.1 importin subunit alpha-8
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20701745 GOA
Cellular Component GO Annotation Evidence Reference Source
part of NLS-dependent protein nuclear import complex IPI
IPI: Inferred from physical interaction
20701745 GOA
located in nucleus IDA
IDA: Inferred from direct assay
36647821 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNA7 Protein Structure

IBB

IBB: Importin beta binding domain (7 - 92)

Arm

Arm: Armadillo/beta-catenin-like repeat (104 - 143)

Arm

Arm: Armadillo/beta-catenin-like repeat (145 - 184)

Arm

Arm: Armadillo/beta-catenin-like repeat (188 - 228)

Arm

Arm: Armadillo/beta-catenin-like repeat (234 - 270)

Arm

Arm: Armadillo/beta-catenin-like repeat (276 - 311)

Arm

Arm: Armadillo/beta-catenin-like repeat (314 - 354)

Arm

Arm: Armadillo/beta-catenin-like repeat (358 - 395)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 516 a.a.
Protein Preferred Names Protein Names

importin subunit alpha-8

karyopherin alpha 7

Related Diseases

Diseases Alias
Partial Corpus Callosum Agenesis-Cerebellar Vermis Hypoplasia With Posterior Fossa Cysts Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07421 KPNA7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KPNA7 RGD RGD:1594749
Mus musculus KPNA7 MGD MGI:2141165
Canis familiaris KPNA7 VGNC VGNC:42505
Bos taurus KPNA7 VGNC VGNC:30706
Macaca mulatta KPNA7 VGNC VGNC:74101
Felis catus KPNA7 VGNC VGNC:63166