YY2 - YY2 transcription factor Gene

Homo sapiens

Also known as ZNF631

Gene ID: 404281 | Gene type: protein coding

About YY2

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:21,855,987-21,858,740 (from NCBI)

This gene has 1 transcript (splice variant), 21 orthologues and 2 paralogues.

Summary

The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]

YY2 Products(1)

mRNA	Protein	Name
NM_206923.4	NP_996806.2	transcription factor YY2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15087442	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16260628	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15087442	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16260628	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	16260628	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YY2 Protein Structure

zf-C2H2_4

zf-H2C2_2

0
100
200
300
372 a.a.

Protein Preferred Names

Protein Names

transcription factor YY2

transcription factor yin yang 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1321	GR231118	Antagonist	/	Unkown
HY-RS15948	YY2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	YY2	MGD	MGI:3837947
Rattus norvegicus	YY2	RGD	RGD:2324567

Name
Email *

	Sorry, but the email address you supplied was invalid.